Genomics
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Regulatory Regions Displayer
16 Alleles
| DB identifier | Symbol | Allele Class | Organism |
|---|---|---|---|
| FBal0192641 | mad2[EY21687] | Drosophila melanogaster | |
| FBal0276823 | mad2[unspecified] | Drosophila melanogaster | |
| FBal0178960 | mad2[c07120] | Drosophila melanogaster | |
| FBal0178961 | mad2[c06928] | Drosophila melanogaster | |
| FBal0243478 | mad2[Ubi-p63E.T:Avic\GFP-S65T] | Drosophila melanogaster | |
| FBal0277486 | mad2[G6595] | Drosophila melanogaster | |
| FBal0277487 | mad2[Scer\UAS.T:Avic\GFP-EGFP] | Drosophila melanogaster | |
| FBal0189944 | mad2[T:Avic\GFP-S65T] | Drosophila melanogaster | |
| FBal0287252 | mad2[Scer\UAS.ORF] | Drosophila melanogaster | |
| FBal0287253 | mad2[Scer\UAS.ORF.T:Ivir\HA1] | Drosophila melanogaster | |
| FBal0266843 | mad2[T:Disc\RFP-mRFP] | Drosophila melanogaster | |
| FBal0210040 | mad2[GD16427] | Drosophila melanogaster | |
| FBal0210039 | mad2[GD9396] | Drosophila melanogaster | |
| FBal0247990 | mad2[Delta] | Drosophila melanogaster | |
| FBal0235328 | mad2[KK108038] | Drosophila melanogaster | |
| FBal0272625 | mad2[NIG.17498R] | Drosophila melanogaster |
16 Clones
2 UTRs
| Class | DB identifier |
Organism . Name |
|---|---|---|
| FivePrimeUTR | FBtr0077113-5-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0077113-3-prime-utr | Drosophila melanogaster |
Other
13 Pathways
- Mitotic Spindle Checkpoint,
- Cdc20:Phospho-APC/C mediated degradation of Cyclin A,
- APC-Cdc20 mediated degradation of Nek2A,
- Cell Cycle, Mitotic,
- Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components,
- Cell Cycle Checkpoints,
- Cell Cycle,
- Amplification of signal from the kinetochores,
- APC/C-mediated degradation of cell cycle proteins,
- Regulation of APC/C activators between G1/S and early anaphase,
- Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal,
- Regulation of mitotic cell cycle,
- Inactivation of APC/C via direct inhibition of the APC/C complex
2 Cross References
| Identifier |
Source . Name |
Subject . Primary Identifier |
|---|---|---|
| 38656 | NCBI Entrez Gene identifiers | FBgn0035640 |
| 64116 | BioGRID | FBgn0035640 |
11 Data Sets
| Name | URL |
|---|---|
| FlyBase data set for Drosophila melanogaster | |
| TrEMBL data set | http://www.ebi.ac.uk/trembl/ |
| Drosophila 12 Genomes Consortium homology | |
| GenomeRNAi data set | |
| TreeFam data set | |
| Panther data set | |
| IntAct interactions data set | |
| BioGRID interaction data set | http://www.thebiogrid.org/downloads.php |
| GO Annotation from FlyBase | |
| FlyBase fasta data set for Drosophila melanogaster | |
| Drosophila Cell Line and Developmental Stage Gene and Exon Scores |
55 Expression Scores
2 Introns
| DB identifier |
Organism . Name |
|---|---|
| intron_FBgn0035640:3_FBgn0035640:2 | Drosophila melanogaster |
| intron_FBgn0035640:2_FBgn0035640:1 | Drosophila melanogaster |
26 RNAi Results
| Screen | Gene | Phenotype | Score | Conditions | PubMed ID |
|---|---|---|---|---|---|
| Lipid storage | mad2 | none | 0.196531821 | 19067489 | |
| Lipid storage | mad2 | none | -1.035404298 | 19067489 | |
| Multipolar division | mad2 | Centrosome clustering defects | strong | 18662975 | |
| Cell morphology | mad2 | Morphology | np | 14527345 | |
| Intracellular Listeria monocytogenes infection | mad2 | Increased GFP protein expression | moderate | 16020693 | |
| Innate immunity | mad2 | Decreased IMD/Rel reporter activity | -3.8 | 16170305 | |
| Cell size and cell-cycle regulation (1) | mad2 | none | sp | 16496002 | |
| Muscle morphogenesis and function (1) | mad2 | Lethal | np | 20220848 | |
| Muscle morphogenesis and function (1) | mad2 | Lethal | np | 20220848 | |
| Muscle morphogenesis and function (1) | mad2 | Lethal | np | 20220848 | |
| Muscle morphogenesis and function (1) | mad2 | Lethal | np | 20220848 | |
| Muscle morphogenesis and function (2) | mad2 | Wing posture / locomotion / ability to fly defect or lethal / semi-lethal | np | 20220848 | |
| Heat nociception (1) | mad2 | none | -1.17 | 21074052 | |
| Heart development and function (1) | mad2 | none | 1 | 20371351 | |
| Heart development and function (1) | mad2 | none | 1 | 20371351 | |
| Serratia marcescens infection (1) | mad2 | none | 0.455223880597014 | 19520911 | |
| Serratia marcescens infection (1) | mad2 | none | 0.443298969072164 | 19520911 | |
| Notch pathway regulation (4) | mad2 | none | 0 | 19363474 | |
| Notch pathway regulation (4) | mad2 | none | 0 | 19363474 | |
| Self-renewal and differentiation in neural stem cells | mad2 | GFP aggregates number, GFP aggregates size, lethal | sp | 21549331 | |
| Adiposity regulation (1) | mad2 | none | -0.433 | 20074523 | |
| Adiposity regulation (1) | mad2 | none | -0.371 | 20074523 | |
| Blood cell homeostasis regulation (1) | mad2 | none | np | 20540764 | |
| Blood cell homeostasis regulation (2) | mad2 | none | np | 20540764 | |
| Hippo pathway regulation | mad2 | none | 0.78 | 23263283 | |
| Glycosylation regulation (1) | mad2 | none | sp | 21203496 |
