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Gene : Akt1 D. melanogaster

DB identifier  ? FBgn0010379 Secondary Identifier  ? CG4006
Name  ? Akt1 Source  FlyBase
  • synonyms:
  • FBan0004006,
  • CG4006,
  • FBgn0017365,
  • dAkt kinase,
  • D-Akt,
  • FBgn0010837,
  • PKB/dAKT,
  • l(3)89Bq,
  • DAKT1,
  • pAkt,
  • Akt1|PKB,
  • related to the A and C kinases,
  • p-Akt,
  • DRAC-PK,
  • Related to PKA to PKC protein kinases,
  • AKT/PKB,
  • l(3)04226,
  • FBgn0010379,
  • dAKT/dPKB,
  • DAKT1/PKB,
  • RAC,
  • DPKB,
  • AKT1,
  • PKB/AKT,
  • dAkt/PKB,
  • DAkt,
  • Protein kinase B,
  • FBgn0013324,
  • PKB,
  • RacPK,
  • DRAC-PK66; DRAC-PK85,
  • AKT,
  • Akt kinase

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37 Alleles

DB identifier Symbol Allele Class Organism
FBal0257056 Akt1[HMS00007]   Drosophila melanogaster
FBal0245310 Akt1[HM04007]   Drosophila melanogaster
FBal0188236 Akt1[c02098]   Drosophila melanogaster
FBal0162822 Akt1[EY10012]   Drosophila melanogaster
FBal0285731 Akt1[Scer\UAS.T:Uuuu\Myr5]   Drosophila melanogaster
FBal0215851 Akt1[tub.PH]   Drosophila melanogaster
FBal0215852 Akt1[R45A.tub]   Drosophila melanogaster
FBal0215853 Akt1[T342A.tub]   Drosophila melanogaster
FBal0215854 Akt1[S505A.tub]   Drosophila melanogaster
FBal0150983 Akt1[Act5C.T:Myr-Src64B]   Drosophila melanogaster
FBal0243540 Akt1[04226] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0089844 Akt1[2]   Drosophila melanogaster
FBal0089842 Akt1[hs.PS]   Drosophila melanogaster
FBal0188235 Akt1[dsRNA.cSa]   Drosophila melanogaster
FBal0157363 Akt1[T342D.S505D.GMR]   Drosophila melanogaster
FBal0157365 Akt1[GMR.Exel]   Drosophila melanogaster
FBal0188234 Akt1[unspecified]   Drosophila melanogaster
FBal0145226 Akt1[hs.PV]   Drosophila melanogaster
FBal0150981 Akt1[dsRNA.cPa]   Drosophila melanogaster
FBal0051404 Akt1[1] loss of function allele Drosophila melanogaster
FBal0190593 Akt1[6M4]   Drosophila melanogaster
FBal0124421 Akt1[3] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0145227 Akt1[K214M.hs]   Drosophila melanogaster
FBal0157366 Akt1[Act5C.T:Zzzz\FLAG]   Drosophila melanogaster
FBal0145225 Akt1[hs.T:Uuuu\Myr4]   Drosophila melanogaster
FBal0136146 Akt1[Scer\UAS.cRa]   Drosophila melanogaster
FBal0089843 Akt1[Scer\UAS.cSa]   Drosophila melanogaster
FBal0157364 Akt1[Scer\UAS.Exel]   Drosophila melanogaster
FBal0137673 Akt1[Scer\UAS.T:Ivir\HA1,T:Uuuu\MyrPalm1]   Drosophila melanogaster
FBal0124420 Akt1[Scer\UAS.T:Ivir\HA1]   Drosophila melanogaster

154 Clones

Secondary Identifier DB identifier
ESG018b.E21.1_E07 FBcl0006181
EK157722 FBcl0054578
EK303304 FBcl0054766
EK291737 FBcl0054770
EK217018 FBcl0054814
EK142240 FBcl0054820
EK045038 FBcl0054826
EK187758 FBcl0054830
EK142211 FBcl0054878
EK142205 FBcl0054882
EK142238 FBcl0054900
EK142237 FBcl0054906
EK142241 FBcl0054912
EK119205 FBcl0054920
EK303601 FBcl0054930
EK137410 FBcl0054936
EK307464 FBcl0054954
EK089016 FBcl0054958
EK153739 FBcl0054964
EK137407 FBcl0054968
EK142208 FBcl0054974
EK170963 FBcl0054984
EK165934 FBcl0054990
EK142243 FBcl0054994
EK142244 FBcl0054996
EK142246 FBcl0055002
EK137446 FBcl0055006
EK142247 FBcl0055012
EK276040 FBcl0055016
EK065017 FBcl0055026

9 Exons

DB identifier Symbol
FBgn0010379:3 Akt1:3
FBgn0010379:1 Akt1:1
FBgn0010379:4 Akt1:4
FBgn0010379:5 Akt1:5
FBgn0010379:6 Akt1:6
FBgn0010379:7 Akt1:7
FBgn0010379:8 Akt1:8
FBgn0010379:9 Akt1:9
FBgn0010379:2 Akt1:2

4 Transcripts

DB identifier Gene
FBtr0344470 Akt1
FBtr0083226 Akt1
FBtr0083228 Akt1
FBtr0083227 Akt1

8 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0083226-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0083227-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0083228-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0344470-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0083226-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0083227-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0083228-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0344470-3-prime-utr Drosophila melanogaster

Interactions

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Other

94 Pathways

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
41957 NCBI Entrez Gene identifiers FBgn0010379
67008 BioGRID FBgn0010379

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0010379 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 1094.0
FBgn0010379 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 1000.0
FBgn0010379 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 432.0
FBgn0010379 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 573.0
FBgn0010379 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 797.0
FBgn0010379 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 1141.0
FBgn0010379 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 1763.0
FBgn0010379 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 1115.0
FBgn0010379 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 943.0
FBgn0010379 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 2108.0
FBgn0010379 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 1998.0
FBgn0010379 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 812.0
FBgn0010379 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 1629.0
FBgn0010379 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 1354.0
FBgn0010379 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 1034.0
FBgn0010379 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 926.0
FBgn0010379 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 1014.0
FBgn0010379 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 687.0
FBgn0010379 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 1115.0
FBgn0010379 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 1208.0
FBgn0010379 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 1073.0
FBgn0010379 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 1563.0
FBgn0010379 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 834.0
FBgn0010379 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 1355.0
FBgn0010379 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 1029.0
FBgn0010379 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 2315.0
FBgn0010379 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 1432.0
FBgn0010379 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 1796.0
FBgn0010379 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 1331.0
FBgn0010379 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 1449.0

8 Introns

DB identifier
Organism . Name
intron_FBgn0010379:1_FBgn0010379:4 Drosophila melanogaster
intron_FBgn0010379:4_FBgn0010379:5 Drosophila melanogaster
intron_FBgn0010379:5_FBgn0010379:6 Drosophila melanogaster
intron_FBgn0010379:6_FBgn0010379:7 Drosophila melanogaster
intron_FBgn0010379:7_FBgn0010379:8 Drosophila melanogaster
intron_FBgn0010379:8_FBgn0010379:9 Drosophila melanogaster
intron_FBgn0010379:2_FBgn0010379:4 Drosophila melanogaster
intron_FBgn0010379:3_FBgn0010379:4 Drosophila melanogaster

47 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Cell size regulation Akt1 none -0.31   19216764
Lipid storage Akt1 none 0.180274667   19067489
Lipid storage Akt1 none -0.102105052   19067489
ERK signaling Akt1 ERK activation increased strong   17086199
Cell morphology Akt1 Morphology np   14527345
Cell cycle regulation (1) Akt1 none np   15616552
Cell cycle regulation (2) Akt1 none np   15616552
Cell size and cell-cycle regulation (1) Akt1 Increased G1 DNA content, decreased G2 DNA content sp   16496002
Cell size and cell-cycle regulation (1) Akt1 none sp   16496002
Cell size and cell-cycle regulation (1) Akt1 none sp   16496002
Cell size and cell-cycle regulation (1) Akt1 none sp   16496002
Cell size and cell-cycle regulation (1) Akt1 none sp   16496002
Cell size and cell-cycle regulation (2) Akt1 none 1.336   16496002
Cell size and cell-cycle regulation (3) Akt1 none 456   16496002
Cell size and cell-cycle regulation (4) Akt1 none below threshold   16496002
P. aeruginosa infection Akt1 P. aeruginosa invasion decreased np   18369477
DFoxO signaling Akt1 Decreased dFoxO reporter activity 0.08   18815370
Combinatorial effect with methyl methanesulphonate (2) Akt1 none sp   19543366
Muscle morphogenesis and function (1) Akt1 Lethal np   20220848
Muscle morphogenesis and function (1) Akt1 Lethal np   20220848
Muscle morphogenesis and function (2) Akt1 Wing posture / locomotion / ability to fly defect or lethal / semi-lethal np   20220848
Muscle morphogenesis and function (3) Akt1 Clumpy Z-line (irregular aggregates) np   20220848
Heat nociception (1) Akt1 Developmentally lethal 0   21074052
Heart development and function (1) Akt1 Adult lethal 0.6   20371351
Heart development and function (2) Akt1 none 2.91   20371351
Serratia marcescens infection (1) Akt1 Decreased viability after Serratia marcescens infection -3.30985915492957   19520911
Serratia marcescens infection (2) Akt1 none sp   19520911
Serratia marcescens infection (4) Akt1 none sp   19520911
Notch pathway regulation (4) Akt1 Completely lethal (pupal) sp   19363474
Akt-TOR pathway negative feedback regulation Akt1 Decreased dAkt phosphorylation after insulin stimulation -9.8 10 min insulin stimulation 20585550

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