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Gene : drk D. melanogaster

DB identifier  ? FBgn0004638 Secondary Identifier  ? CG6033
Name  ? downstream of receptor kinase Source  FlyBase
  • synonyms:
  • 24/1,
  • FBan0006033,
  • l(2)k13809,
  • Grb2/drk,
  • FBgn0021869,
  • Enhancer of sevenless-2B,
  • downstream of receptor kinases,
  • DRK,
  • crkl,
  • P1112,
  • GRB2,
  • E(sev)2B,
  • Drk/Grb2,
  • downstream receptor kinase,
  • Su(sev)R1,
  • FBgn0004638,
  • l(2)10626,
  • Grb/drk,
  • CG6033,
  • Grb-2,
  • Downstream of receptor kinase

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42 Alleles

DB identifier Symbol Allele Class Organism
FBal0195715 drk[KG03077]   Drosophila melanogaster
FBal0281549 drk[HMS02547]   Drosophila melanogaster
FBal0211973 drk[CB02974]   Drosophila melanogaster
FBal0064117 drk[k13809]   Drosophila melanogaster
FBal0246431 drk[hs.PM]   Drosophila melanogaster
FBal0245651 drk[JF01377]   Drosophila melanogaster
FBal0003116 drk[10626]   Drosophila melanogaster
FBal0064897 drk[k15709]   Drosophila melanogaster
FBal0064899 drk[k13913]   Drosophila melanogaster
FBal0243574 drk[EDA]   Drosophila melanogaster
FBal0122997 drk[EP2477]   Drosophila melanogaster
FBal0042995 drk[k02401]   Drosophila melanogaster
FBal0042996 drk[k03106]   Drosophila melanogaster
FBal0246432 drk[dsRNA.Sym.Scer\UAS]   Drosophila melanogaster
FBal0031082 drk[hs.sev]   Drosophila melanogaster
FBal0042992 drk[SH3(N)SH2.hs.sev]   Drosophila melanogaster
FBal0042993 drk[W189A.hs.sev]   Drosophila melanogaster
FBal0042994 drk[W36A.hs.sev]   Drosophila melanogaster
FBal0045517 drk[E(sev)2B.sev]   Drosophila melanogaster
FBal0093083 drk[P49L.G199R.Act5C]   Drosophila melanogaster
FBal0261825 drk[CPTI002249]   Drosophila melanogaster
FBal0031080 drk[R1] loss of function allele, hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0042991 drk[DeltaP24]   Drosophila melanogaster
FBal0120513 drk[TZ160]   Drosophila melanogaster
FBal0093084 drk[P49L.Act5C]   Drosophila melanogaster
FBal0175706 drk[dsRNA.cIa]   Drosophila melanogaster
FBal0060442 drk[S11]   Drosophila melanogaster
FBal0060443 drk[unspecified]   Drosophila melanogaster
FBal0287941 drk[e0A] antimorphic allele - genetic evidence Drosophila melanogaster
FBal0093080 drk[R85K.Act5C]   Drosophila melanogaster

135 Clones

Secondary Identifier DB identifier
DPiM_LD12029 FBcl0742140
173035 FBcl0422831
ESG019b.E21.2_C11 FBcl0000922
ESG017c.B21.1_G01 FBcl0004485
AT28906 FBcl0015701
AT29160 FBcl0015721
AT26682 FBcl0015731
AT30234 FBcl0015773
AT13295 FBcl0015787
AT19817 FBcl0015983
bs82g04 FBcl0049361
EC38449 FBcl0064289
EC31249 FBcl0064381
EK136439 FBcl0075710
EK133951 FBcl0076704
EK179956 FBcl0077240
EK237030 FBcl0077528
EK203262 FBcl0077540
EK308522 FBcl0077552
EK265704 FBcl0077564
EK166317 FBcl0077580
EK034532 FBcl0077586
EK160938 FBcl0077600
EK259340 FBcl0077608
EK059939 FBcl0077616
EK180960 FBcl0077624
EK129662 FBcl0077634
EK220809 FBcl0077642
EK178531 FBcl0077654
EK178807 FBcl0077664

12 Exons

DB identifier Symbol
FBgn0004638:10 drk:10
FBgn0004638:1 drk:1
FBgn0004638:7 drk:7
FBgn0004638:9 drk:9
FBgn0004638:12 drk:12
FBgn0004638:8 drk:8
FBgn0004638:6 drk:6
FBgn0004638:5 drk:5
FBgn0004638:4 drk:4
FBgn0004638:3 drk:3
FBgn0004638:11 drk:11
FBgn0004638:2 drk:2

5 Transcripts

DB identifier Gene
FBtr0087696 drk
FBtr0087697 drk
FBtr0087698 drk
FBtr0087694 drk
FBtr0087695 drk

10 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0087694-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0087695-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0087696-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0087697-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0087698-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0087694-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0087695-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0087696-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0087697-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0087698-3-prime-utr Drosophila melanogaster

Interactions

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Other

0 Pathways

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
36497 NCBI Entrez Gene identifiers FBgn0004638
62256 BioGRID FBgn0004638

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0004638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 2377.0
FBgn0004638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 2433.0
FBgn0004638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 1668.0
FBgn0004638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 1794.0
FBgn0004638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 2240.0
FBgn0004638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 3508.0
FBgn0004638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 3427.0
FBgn0004638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 1794.0
FBgn0004638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 2856.0
FBgn0004638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 2314.0
FBgn0004638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 3080.0
FBgn0004638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 1628.0
FBgn0004638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 1988.0
FBgn0004638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 2960.0
FBgn0004638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 2271.0
FBgn0004638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 2792.0
FBgn0004638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 2288.0
FBgn0004638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 2703.0
FBgn0004638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 3242.0
FBgn0004638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 2700.0
FBgn0004638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 1934.0
FBgn0004638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 4863.0
FBgn0004638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 1878.0
FBgn0004638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 3319.0
FBgn0004638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 3442.0
FBgn0004638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 4726.0
FBgn0004638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 4872.0
FBgn0004638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 4579.0
FBgn0004638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 3664.0
FBgn0004638 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 4266.0

12 Introns

DB identifier
Organism . Name
intron_FBgn0004638:10_FBgn0004638:8 Drosophila melanogaster
intron_FBgn0004638:8_FBgn0004638:6 Drosophila melanogaster
intron_FBgn0004638:6_FBgn0004638:5 Drosophila melanogaster
intron_FBgn0004638:5_FBgn0004638:4 Drosophila melanogaster
intron_FBgn0004638:4_FBgn0004638:1 Drosophila melanogaster
intron_FBgn0004638:10_FBgn0004638:7 Drosophila melanogaster
intron_FBgn0004638:7_FBgn0004638:6 Drosophila melanogaster
intron_FBgn0004638:9_FBgn0004638:6 Drosophila melanogaster
intron_FBgn0004638:12_FBgn0004638:8 Drosophila melanogaster
intron_FBgn0004638:4_FBgn0004638:3 Drosophila melanogaster
intron_FBgn0004638:11_FBgn0004638:8 Drosophila melanogaster
intron_FBgn0004638:4_FBgn0004638:2 Drosophila melanogaster

17 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Cell size regulation drk Decreased cell size -3.73   19216764
Lipid storage drk none 1.009218014   19067489
Lipid storage drk none 1.545419276   19067489
ERK signaling drk ERK activation reduced strong   17086199
Cell morphology drk Morphology np   14527345
Cell size and cell-cycle regulation (1) drk none sp   16496002
P. aeruginosa infection drk P. aeruginosa invasion decreased np   18369477
PGN-induced dJNK phosphorylation drk Increased P-JNK protein expression with PGN 2.44 60 min PGN induction 19893628
Akt-TOR pathway negative feedback regulation drk Decreased dAkt phosphorylation after insulin stimulation -2.8 10 min insulin stimulation 20585550
Notch pathway regulation (1) drk Upregulation of Notch pathway np   20493818
RTK-Ras-ERK pathway regulation (1) drk Decreased ERK phosphorylation after EGF stimulation -2.64 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) drk none -0.42 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) drk Decreased ERK phosphorylation after sSpitz and EGF stimulation -3.52 30 minutes sSpitz stimulation 22028469
RTK-Ras-ERK pathway regulation (2) drk none -1.1 10 minutes sSpitz stimulation 22028469
Hippo pathway regulation drk none 2.12   23263283
Glycosylation regulation (1) drk Decreased mannose Chp glycosylation sp   21203496
Glycosylation regulation (2) drk none np   21203496

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