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Gene : HLH106 D. melanogaster
DB identifier  ? FBgn0261283 Secondary Identifier  ? CG8522
Name  ? Helix loop helix protein 106 Source  FlyBase
  • synonyms:
  • FBgn0261283,
  • l(3)76BDw,
  • FBan0008522,
  • lethal (3) 76BDw,
  • sterol-responsive element-binding protein,
  • CG8522,
  • Sterol regulatory element-binding protein,
  • FBgn0063456,
  • FBgn0015234,
  • HlH106,
  • FBgn0260652,
  • transcription factor Sterol regulatory element binding protein,
  • Sterol Regulatory Element Binding Protein,
  • SREBP,
  • dSREBP,
  • Drosophila sterol regulatory element binding protein
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36 Alleles

DB identifier Symbol Allele Class Organism
FBal0220936 HLH106[G8480]   Drosophila melanogaster
FBal0277279 HLH106[1-452.Scer\UAS]   Drosophila melanogaster
FBal0246373 HLH106[2]   Drosophila melanogaster
FBal0246374 HLH106[3]   Drosophila melanogaster
FBal0282541 HLH106[miRNA.Scer\UAS]   Drosophila melanogaster
FBal0258306 HLH106[dsRNA.Scer\UAS]   Drosophila melanogaster
FBal0284504 HLH106[Z6151]   Drosophila melanogaster
FBal0183329 HLH106[c03318]   Drosophila melanogaster
FBal0183328 HLH106[d08008]   Drosophila melanogaster
FBal0147883 HLH106[52]   Drosophila melanogaster
FBal0091749 HLH106[Act5C.PR]   Drosophila melanogaster
FBal0135981 HLH106[dsRNA.cRa]   Drosophila melanogaster
FBal0141727 HLH106[dsRNA.cSa]   Drosophila melanogaster
FBal0263086 HLH106[HMS00080]   Drosophila melanogaster
FBal0141732 HLH106[1-451.Act5C.T:Hsim\gD]   Drosophila melanogaster
FBal0141731 HLH106[Act5C.T:Hsim\gD]   Drosophila melanogaster
FBal0156414 HLH106[Cdel.Scer\UAS] gain of function allele Drosophila melanogaster
FBal0141730 HLH106[Chit.T:Hsim\gD]   Drosophila melanogaster
FBal0141729 HLH106[N462P.Act5C.T:Hsim\gD]   Drosophila melanogaster
FBal0156412 HLH106[Ndel.Scer\UAS]   Drosophila melanogaster
FBal0156413 HLH106[NTdel.Scer\UAS] antimorphic allele - genetic evidence Drosophila melanogaster
FBal0141728 HLH106[R486A.Act5C.T:Hsim\gD]   Drosophila melanogaster
FBal0156411 HLH106[Scer\UAS.Exel]   Drosophila melanogaster
FBal0156410 HLH106[Scer\UAS.T:Ocun\CYP2C1] antimorphic allele - genetic evidence Drosophila melanogaster
FBal0219684 HLH106[1]   Drosophila melanogaster
FBal0287122 HLH106[Scer\UAS.ORF]   Drosophila melanogaster
FBal0287123 HLH106[Scer\UAS.ORF.T:Ivir\HA1]   Drosophila melanogaster
FBal0241323 HLH106[Scer\UAS.cKa]   Drosophila melanogaster
FBal0241324 HLH106[+t8.7]   Drosophila melanogaster
FBal0241325 HLH106[T:Scer\GAL4,T:Hsim\VP16]   Drosophila melanogaster

47 Clones

Secondary Identifier DB identifier
ESG0111a.B21.1_B06 FBcl0003915
EN03418 FBcl0094217
GH06138 FBcl0109173
GH10860 FBcl0109525
EK106301 FBcl0133392
EK206518 FBcl0133436
EK053729 FBcl0133502
EK219324 FBcl0134310
EK245831 FBcl0134442
HL01847 FBcl0149083
LD04332 FBcl0153275
LP12374 FBcl0182001
RE30381 FBcl0201097
RH13547 FBcl0247141
RH41520 FBcl0247224
RH61422 FBcl0247314
SD19878 FBcl0281006
SD19117 FBcl0281007
SD05333 FBcl0281013
SD27792 FBcl0281015
SD04874 FBcl0281017
SD21767 FBcl0281020
SD21793 FBcl0281024
SD25044 FBcl0281054
FGX001A06 FBcl0393953
CK01.62D.C7 FBcl0451130
CK01.66A.H1 FBcl0451136
CK01.21A.D11 FBcl0451145
523096 FBcl0451151
475293 FBcl0451152

11 Exons

DB identifier Symbol
FBgn0261283:2 HLH106:2
FBgn0261283:8 HLH106:8
FBgn0261283:9 HLH106:9
FBgn0261283:1 HLH106:1
FBgn0261283:4 HLH106:4
FBgn0261283:6 HLH106:6
FBgn0261283:7 HLH106:7
FBgn0261283:10 HLH106:10
FBgn0261283:11 HLH106:11
FBgn0261283:3 HLH106:3
FBgn0261283:5 HLH106:5

4 Transcripts

DB identifier Gene
FBtr0333877 HLH106
FBtr0074873 HLH106
FBtr0074875 HLH106
FBtr0074874 HLH106

8 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0074873-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0074874-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0074875-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0333877-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0074873-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0074874-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0074875-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0333877-3-prime-utr Drosophila melanogaster

Interactions

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Other

9 Pathways

2 Cross References

Identifier
Source . Name
Subject . Primary Identifier
40155 NCBI Entrez Gene identifiers FBgn0261283
65424 BioGRID FBgn0261283

10 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
TrEMBL data set http://www.ebi.ac.uk/trembl/
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  

0 Expression Scores

13 Introns

DB identifier
Organism . Name
intron_FBgn0261283:1_FBgn0261283:2 Drosophila melanogaster
intron_FBgn0261283:2_FBgn0261283:5 Drosophila melanogaster
intron_FBgn0261283:5_FBgn0261283:7 Drosophila melanogaster
intron_FBgn0261283:7_FBgn0261283:8 Drosophila melanogaster
intron_FBgn0261283:8_FBgn0261283:9 Drosophila melanogaster
intron_FBgn0261283:9_FBgn0261283:10 Drosophila melanogaster
intron_FBgn0261283:10_FBgn0261283:11 Drosophila melanogaster
intron_FBgn0261283:1_FBgn0261283:4 Drosophila melanogaster
intron_FBgn0261283:4_FBgn0261283:6 Drosophila melanogaster
intron_FBgn0261283:6_FBgn0261283:7 Drosophila melanogaster
intron_FBgn0261283:1_FBgn0261283:3 Drosophila melanogaster
intron_FBgn0261283:3_FBgn0261283:6 Drosophila melanogaster
intron_FBgn0261283:1_FBgn0261283:5 Drosophila melanogaster

36 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage HLH106 none -0.799555048   19067489
Lipid storage HLH106 none 1.226368846   19067489
Chlamydia caviae infection HLH106 Decreased Chlamydia caviae infection np   17967059
Drosophila C virus infection HLH106 Drosophila C virus replication down np   17040126
E. coli / S. aureus infection HLH106 Cell death np   11912489
Intracellular Listeria monocytogenes infection HLH106 Decreased GFP protein expression strong   16020693
Mycobacterial infection (1) - M. fortuitum infection HLH106 Decreased M. fortuitum intracellular infection 8.2 measurement after 3 days 16020694
Mycobacterial infection (2) - E. coli phagocytosis HLH106 Decreased E. coli phagocytosis np   16020694
Constitutive protein secretion and Golgi organization (1) HLH106 Decreased horseradish peroxidase protein expression sp   16452979
Cell size and cell-cycle regulation (1) HLH106 Decreased G1 DNA content, decreased viability, increased cytokinesis sp   16496002
Cell size and cell-cycle regulation (2) HLH106 none 1.043   16496002
Cell size and cell-cycle regulation (3) HLH106 Decreased cell number 276   16496002
Cell size and cell-cycle regulation (4) HLH106 none below threshold   16496002
Candida albicans phagocytosis (1) HLH106 Decreased Candida albicans phagocytosis np   16336044
Candida albicans phagocytosis (2) HLH106 Decreased Escherichia coli phagocytosis 44   16336044
Candida albicans phagocytosis (3) HLH106 none 45   16336044
Dendrite pattern formation HLH106 none np   16547170
Brucella melitensis infection HLH106 Decreased Brucella melitensis infection 15.67   18654626
Lipid storage HLH106 Fewer lipid droplets, larger size strong   18408709
Mutant human huntingtin aggregation HLH106 Decreased mutant human huntingtin aggregation <= -2   19789644
Muscle morphogenesis and function (1) HLH106 none np   20220848
Muscle morphogenesis and function (1) HLH106 none np   20220848
Heat nociception (1) HLH106 none -1.17   21074052
Heat nociception (1) HLH106 none -1.17   21074052
Heart development and function (1) HLH106 none 1   20371351
Heart development and function (1) HLH106 none 1   20371351
Serratia marcescens infection (1) HLH106 none 0.267605633802816   19520911
Notch pathway regulation (4) HLH106 none 0   19363474
Notch pathway regulation (4) HLH106 none 0   19363474
Adiposity regulation (1) HLH106 none -0.134   20074523

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