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Gene : CSN4 D. melanogaster
DB identifier  ? FBgn0027054 Secondary Identifier  ? CG8725
Name  ? COP9 complex homolog subunit 4 Source  FlyBase
  • synonyms:
  • CG8725,
  • COP9 signalosome subunit 4,
  • l(2)k08018,
  • Cops4,
  • COP9 complex homolog subunit 4,
  • Csn4,
  • CH4,
  • DCH4,
  • Drosophila COP9 signalosome homolog 4,
  • FBan0008725,
  • FBgn0022061,
  • FBgn0027054
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This Gene is in one list:
Fly classI (1496)

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13 Alleles

DB identifier Symbol Allele Class Organism
FBal0281852 CSN4[MI03655]   Drosophila melanogaster
FBal0281143 CSN4[GL01169]   Drosophila melanogaster
FBal0064351 CSN4[k08018]   Drosophila melanogaster
FBal0184455 CSN4[c01101]   Drosophila melanogaster
FBal0160733 CSN4[EY08080]   Drosophila melanogaster
FBal0286540 CSN4[Scer\UAS.ORF]   Drosophila melanogaster
FBal0286541 CSN4[Scer\UAS.ORF.T:Ivir\HA1]   Drosophila melanogaster
FBal0131316 CSN4[N]   Drosophila melanogaster
FBal0156810 CSN4[unspecified]   Drosophila melanogaster
FBal0141865 CSN4[null]   Drosophila melanogaster
FBal0206466 CSN4[GD14010]   Drosophila melanogaster
FBal0230562 CSN4[KK100065]   Drosophila melanogaster
FBal0276123 CSN4[NIG.8725R]   Drosophila melanogaster

36 Clones

Secondary Identifier DB identifier
DPiM_GH09439 FBcl0740930
AT01744 FBcl0030355
AT17810 FBcl0030427
AT16752 FBcl0030455
AT20005 FBcl0030461
AT14877 FBcl0030467
AT01122 FBcl0030479
AT29317 FBcl0030485
GH09439 FBcl0130501
GH14450 FBcl0130527
EK306315 FBcl0135262
EK306956 FBcl0135276
EK233353 FBcl0135346
EK112332 FBcl0135350
GM09654 FBcl0142382
LD11968 FBcl0160943
LD08165 FBcl0160975
LD10641 FBcl0161038
LD32409 FBcl0176418
LD31371 FBcl0176419
LD36387 FBcl0176426
LD43090 FBcl0176429
LD38056 FBcl0176432
LP18246 FBcl0189387
RE07962 FBcl0230844
RE72251 FBcl0230875
RE72217 FBcl0230880
RE53172 FBcl0230887
RE19145 FBcl0230890
RH71171 FBcl0268988

5 Exons

DB identifier Symbol
FBgn0027054:1 CSN4:1
FBgn0027054:2 CSN4:2
FBgn0027054:3 CSN4:3
FBgn0027054:5 CSN4:5
FBgn0027054:4 CSN4:4

2 Transcripts

DB identifier Gene
FBtr0088859 CSN4
FBtr0301230 CSN4

4 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0088859-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0301230-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0088859-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0301230-3-prime-utr Drosophila melanogaster

Interactions

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Other

0 Pathways

2 Cross References

Identifier
Source . Name
Subject . Primary Identifier
35759 NCBI Entrez Gene identifiers FBgn0027054
61621 BioGRID FBgn0027054

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier
Submission . Title
Cell Line . Name
Developmental Stage . Name 		Score
FBgn0027054 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 837.0
FBgn0027054 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 808.0
FBgn0027054 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 752.0
FBgn0027054 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 709.0
FBgn0027054 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 1246.0
FBgn0027054 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 510.0
FBgn0027054 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 538.0
FBgn0027054 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 826.0
FBgn0027054 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 532.0
FBgn0027054 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 864.0
FBgn0027054 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 713.0
FBgn0027054 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 557.0
FBgn0027054 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 1181.0
FBgn0027054 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 566.0
FBgn0027054 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 625.0
FBgn0027054 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 578.0
FBgn0027054 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 768.0
FBgn0027054 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 766.0
FBgn0027054 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 1161.0
FBgn0027054 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 595.0
FBgn0027054 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 728.0
FBgn0027054 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 918.0
FBgn0027054 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 708.0
FBgn0027054 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 541.0
FBgn0027054 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 732.0
FBgn0027054 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 1981.0
FBgn0027054 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 1867.0
FBgn0027054 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 1151.0
FBgn0027054 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 640.0
FBgn0027054 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 641.0

4 Introns

DB identifier
Organism . Name
intron_FBgn0027054:1_FBgn0027054:2 Drosophila melanogaster
intron_FBgn0027054:2_FBgn0027054:3 Drosophila melanogaster
intron_FBgn0027054:3_FBgn0027054:5 Drosophila melanogaster
intron_FBgn0027054:4_FBgn0027054:5 Drosophila melanogaster

30 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage CSN4 none -1.146431596   19067489
Lipid storage CSN4 none -3.108484288   19067489
Intracellular Listeria monocytogenes infection CSN4 Decreased GFP protein expression moderate   16020693
Cell size and cell-cycle regulation (1) CSN4 Increased G1 DNA content, decreased G2 DNA content sp   16496002
Cell size and cell-cycle regulation (2) CSN4 none 1.151   16496002
Cell size and cell-cycle regulation (3) CSN4 Decreased cell number 406   16496002
Cell size and cell-cycle regulation (4) CSN4 none below threshold   16496002
Mutant human huntingtin aggregation CSN4 Increased mutant human huntingtin aggregation >= 2   19789644
Muscle morphogenesis and function (1) CSN4 none np   20220848
Muscle morphogenesis and function (1) CSN4 Day 7 lethal np   20220848
Heat nociception (1) CSN4 none -1.17   21074052
Heat nociception (1) CSN4 none 0.16   21074052
Heart development and function (1) CSN4 none 1   20371351
Serratia marcescens infection (1) CSN4 none 1.4   19520911
Notch pathway regulation (4) CSN4 Gain of bristles, hair cell duplication, bristle morphology defects, notum malformation death, lateral inhibition sp   19363474
Notch pathway regulation (4) CSN4 Gain of bristles, hair cell duplication, bristle morphology defects, notum malformation death, lateral inhibition sp   19363474
Notch pathway regulation (5) CSN4 Bent up (spoon-shaped) wing np   19363474
G2-M DNA damage checkpoint regulation (2) CSN4 Increased histone H3 phosphorylation with bleocin 32.43 with bleocin 21205937
G2-M DNA damage checkpoint regulation (2) CSN4 Increased histone H3 phosphorylation with doxorubicin 37.93 with doxorubicin 21205937
G2-M DNA damage checkpoint regulation (2) CSN4 Increased histone H3 phosphorylation with etoposide 36.5 with etoposide 21205937
G2-M DNA damage checkpoint regulation (2) CSN4 Increased histone H3 phosphorylation after X-ray exposure 52.42 X-ray exposure 21205937
Adiposity regulation (1) CSN4 none 0.307   20074523
Blood cell homeostasis regulation (1) CSN4 Increased melanotic mass formation np   20540764
Blood cell homeostasis regulation (2) CSN4 none np   20540764
RTK-Ras-ERK pathway regulation (1) CSN4 none 0.85 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) CSN4 none 0.45 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) CSN4 Increased ERK phosphorylation after sSpitz and EGF stimulation 2.87 30 minutes sSpitz stimulation 22028469
RTK-Ras-ERK pathway regulation (2) CSN4 Increased ERK phosphorylation after sSpitz and EGF stimulation 2.9 10 minutes sSpitz stimulation 22028469
Hippo pathway regulation CSN4 none 2.64   23263283
Glycosylation regulation (1) CSN4 Decreased Chp protein expression np   21203496

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