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Gene : l(3)mbt D. melanogaster

DB identifier  ? FBgn0002441 Secondary Identifier  ? CG5954
Name  ? lethal (3) malignant brain tumor Source  FlyBase
  • synonyms:
  • FBan0005954,
  • dL(3)mbt,
  • MBT,
  • CG5954,
  • FBgn0002441,
  • L(3)MBT,
  • tumor-supressor,
  • l(3)malignant braintumor,
  • L(3)MBT/LIN-61,
  • L3mbt

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29 Alleles

DB identifier Symbol Allele Class Organism
FBal0264246 l(3)mbt[miRNA.Scer\UAS]   Drosophila melanogaster
FBal0264247 l(3)mbt[Scer\UAS.T:Disc\RFP]   Drosophila melanogaster
FBal0264248 l(3)mbt[Scer\UAS.T:Avic\GFP]   Drosophila melanogaster
FBal0248335 l(3)mbt[6a14]   Drosophila melanogaster
FBal0248336 l(3)mbt[4d30]   Drosophila melanogaster
FBal0248337 l(3)mbt[3d23]   Drosophila melanogaster
FBal0248338 l(3)mbt[5d8]   Drosophila melanogaster
FBal0248339 l(3)mbt[4d16]   Drosophila melanogaster
FBal0248340 l(3)mbt[5d6]   Drosophila melanogaster
FBal0248341 l(3)mbt[6a31]   Drosophila melanogaster
FBal0248342 l(3)mbt[3d33]   Drosophila melanogaster
FBal0179094 l(3)mbt[f02565]   Drosophila melanogaster
FBal0046091 l(3)mbt[P3]   Drosophila melanogaster
FBal0060352 l(3)mbt[+t6.8]   Drosophila melanogaster
FBal0028387 l(3)mbt[ts1]   Drosophila melanogaster
FBal0155051 l(3)mbt[GM161]   Drosophila melanogaster
FBal0046090 l(3)mbt[E2]   Drosophila melanogaster
FBal0155050 l(3)mbt[GM76]   Drosophila melanogaster
FBal0175612 l(3)mbt[dsRNA.cLa]   Drosophila melanogaster
FBal0240880 l(3)mbt[JF02913]   Drosophila melanogaster
FBal0057055 l(3)mbt[unspecified]   Drosophila melanogaster
FBal0155049 l(3)mbt[GM79]   Drosophila melanogaster
FBal0263374 l(3)mbt[HMS01466]   Drosophila melanogaster
FBal0246892 l(3)mbt[G7124]   Drosophila melanogaster
FBal0209887 l(3)mbt[GD4370]   Drosophila melanogaster
FBal0227552 l(3)mbt[CB-5744-3]   Drosophila melanogaster
FBal0227553 l(3)mbt[5-HA-2851]   Drosophila melanogaster
FBal0230931 l(3)mbt[KK100812]   Drosophila melanogaster
FBal0274912 l(3)mbt[NIG.5954R]   Drosophila melanogaster

36 Clones

Secondary Identifier DB identifier
EK250548 FBcl0019528
EK304550 FBcl0019674
EK291132 FBcl0019718
AT08328 FBcl0035245
EP07335 FBcl0086349
LD05287 FBcl0162442
LD06610 FBcl0162448
LD34207 FBcl0178280
LD28140 FBcl0178282
LD29435 FBcl0178283
LD28929 FBcl0178285
LD35376 FBcl0178292
LD46950 FBcl0178307
LD25072 FBcl0178310
LP07193 FBcl0191394
LP13979 FBcl0191397
LP04464 FBcl0191398
LP14791 FBcl0191399
LP18174 FBcl0191401
LP22953 FBcl0191402
RE65061 FBcl0237367
SD01745 FBcl0288752
SD28049 FBcl0288754
EK129143 FBcl0323567
Dmel_neb_012875_0366_3434 FBcl0370973
RP003196759 FBcl0568823
RP003281207 FBcl0568824
RP003042088 FBcl0568825
RP003388036 FBcl0568826
RP003536071 FBcl0568827

5 Exons

DB identifier Symbol
FBgn0002441:5 l(3)mbt:5
FBgn0002441:4 l(3)mbt:4
FBgn0002441:3 l(3)mbt:3
FBgn0002441:2 l(3)mbt:2
FBgn0002441:1 l(3)mbt:1

1 Transcripts

DB identifier Gene
FBtr0085175 l(3)mbt

2 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0085175-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0085175-3-prime-utr Drosophila melanogaster

Interactions

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Other

0 Pathways

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
43288 NCBI Entrez Gene identifiers FBgn0002441
68174 BioGRID FBgn0002441

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
TrEMBL data set http://www.ebi.ac.uk/trembl/
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0002441 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 416.0
FBgn0002441 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 459.0
FBgn0002441 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 476.0
FBgn0002441 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 432.0
FBgn0002441 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 486.0
FBgn0002441 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 282.0
FBgn0002441 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 540.0
FBgn0002441 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 569.0
FBgn0002441 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 639.0
FBgn0002441 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 667.0
FBgn0002441 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 535.0
FBgn0002441 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 307.0
FBgn0002441 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 346.0
FBgn0002441 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 328.0
FBgn0002441 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 579.0
FBgn0002441 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 428.0
FBgn0002441 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 492.0
FBgn0002441 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 543.0
FBgn0002441 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 358.0
FBgn0002441 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 425.0
FBgn0002441 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 475.0
FBgn0002441 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 568.0
FBgn0002441 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 576.0
FBgn0002441 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 514.0
FBgn0002441 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 479.0
FBgn0002441 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 1390.0
FBgn0002441 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 1146.0
FBgn0002441 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 541.0
FBgn0002441 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 439.0
FBgn0002441 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 432.0

4 Introns

DB identifier
Organism . Name
intron_FBgn0002441:5_FBgn0002441:4 Drosophila melanogaster
intron_FBgn0002441:4_FBgn0002441:3 Drosophila melanogaster
intron_FBgn0002441:3_FBgn0002441:2 Drosophila melanogaster
intron_FBgn0002441:2_FBgn0002441:1 Drosophila melanogaster

26 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage l(3)mbt none 1.873291486   19067489
Lipid storage l(3)mbt none 0   19067489
E2F signaling l(3)mbt E2F signaling upregulated np   17517653
Cell size and cell-cycle regulation (1) l(3)mbt none sp   16496002
Dendrite pattern formation l(3)mbt Increased 1st branch extension, decreased lateral branching np   16547170
Combinatorial effect with methyl methanesulphonate (1) l(3)mbt Synthetic lethal with methyl methanesulphonate sp   19543366
Combinatorial effect with methyl methanesulphonate (2) l(3)mbt Synthetic lethal with methyl methanesulphonate sp   19543366
Muscle morphogenesis and function (1) l(3)mbt none np   20220848
Muscle morphogenesis and function (1) l(3)mbt none np   20220848
Heat nociception (1) l(3)mbt none -1.17   21074052
Heart development and function (1) l(3)mbt none 1   20371351
Serratia marcescens infection (1) l(3)mbt none 0.677419354838709   19520911
Notch pathway regulation (4) l(3)mbt none 0   19363474
Notch pathway regulation (4) l(3)mbt none 0   19363474
PGN-induced dJNK phosphorylation l(3)mbt Increased P-JNK protein expression with PGN 3.88 15 min PGN induction 19893628
Notch pathway regulation (1) l(3)mbt Upregulation of Notch pathway np   20493818
Notch pathway regulation (2) l(3)mbt none np C96-GAL4 20493818
Notch pathway regulation (2) l(3)mbt Adult wing veins: disrupted, thinner sp en-GAL4 20493818
Notch pathway regulation (3) l(3)mbt Upregulation of Notch pathway np   20493818
Adiposity regulation (1) l(3)mbt none 0.415   20074523
RTK-Ras-ERK pathway regulation (1) l(3)mbt none 1.37 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) l(3)mbt Decreased ERK phosphorylation after EGF stimulation -1.74 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) l(3)mbt none 1.15 10 minutes sSpitz stimulation 22028469
RTK-Ras-ERK pathway regulation (2) l(3)mbt Increased ERK phosphorylation after sSpitz and EGF stimulation 2.08 30 minutes sSpitz stimulation 22028469
Hippo pathway regulation l(3)mbt none 2.86   23263283
Glycosylation regulation (1) l(3)mbt none sp   21203496

0 Submissions