Genomics
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8 Alleles
| DB identifier | Symbol | Allele Class | Organism |
|---|---|---|---|
| FBal0284512 | RpL8[Scer\UAS.T:Disc\RFP] | Drosophila melanogaster | |
| FBal0280383 | RpL8[Scer\UAS.cXa] | Drosophila melanogaster | |
| FBal0280384 | RpL8[dsRNA.Scer\UAS] | Drosophila melanogaster | |
| FBal0287204 | RpL8[Scer\UAS.ORF] | Drosophila melanogaster | |
| FBal0287205 | RpL8[Scer\UAS.ORF.T:Ivir\HA1] | Drosophila melanogaster | |
| FBal0208362 | RpL8[GD7780] | Drosophila melanogaster | |
| FBal0219303 | RpL8[DG02501] | Drosophila melanogaster | |
| FBal0235270 | RpL8[KK107946] | Drosophila melanogaster |
851 Clones
4 Exons
| DB identifier | Symbol |
|---|---|
| FBgn0261602:1 | RpL8:1 |
| FBgn0261602:3 | RpL8:3 |
| FBgn0261602:4 | RpL8:4 |
| FBgn0261602:2 | RpL8:2 |
4 UTRs
| Class | DB identifier |
Organism . Name |
|---|---|---|
| FivePrimeUTR | FBtr0072924-5-prime-utr | Drosophila melanogaster |
| FivePrimeUTR | FBtr0072925-5-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0072924-3-prime-utr | Drosophila melanogaster |
| ThreePrimeUTR | FBtr0072925-3-prime-utr | Drosophila melanogaster |
Other
49 Pathways
- Eukaryotic Translation Elongation,
- Transcription,
- Nonsense Mediated Decay Enhanced by the Exon Junction Complex,
- SLBP independent Processing of Histone Pre-mRNAs,
- RNA Polymerase II Transcription,
- RNA Polymerase II Transcription Pre-Initiation And Promoter Opening,
- Transport of Mature Transcript to Cytoplasm,
- Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S,
- SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs,
- RNA Polymerase II Pre-transcription Events,
- RNA Polymerase II Transcription Initiation And Promoter Clearance,
- Transport of Mature mRNA derived from an Intron-Containing Transcript,
- Nonsense Mediated Decay Independent of the Exon Junction Complex,
- Gene Expression,
- Post-Elongation Processing of Intronless pre-mRNA,
- Processing of Intronless Pre-mRNAs,
- Processing of Capped Intronless Pre-mRNA,
- Cap-dependent Translation Initiation,
- Formation of a pool of free 40S subunits,
- Cleavage of Growing Transcript in the Termination Region,
- Eukaryotic Translation Initiation,
- Post-Elongation Processing of the Transcript,
- Metabolism of proteins,
- Translation,
- mRNA Capping,
- Processing of Capped Intron-Containing Pre-mRNA,
- Formation of the Early Elongation Complex,
- Metabolism of RNA,
- GTP hydrolysis and joining of the 60S ribosomal subunit,
- Metabolism of mRNA,
- Transport of Mature mRNAs Derived from Intronless Transcripts,
- RNA Polymerase II Transcription Termination,
- Transport of the SLBP Dependant Mature mRNA,
- Transport of Mature mRNA Derived from an Intronless Transcript,
- RNA Pol II CTD phosphorylation and interaction with CE,
- Transport of the SLBP independent Mature mRNA,
- SRP-dependent cotranslational protein targeting to membrane,
- 3' -UTR-mediated translational regulation,
- RNA Polymerase II Transcription Initiation,
- RNA Polymerase II Transcription Elongation,
- L13a-mediated translational silencing of Ceruloplasmin expression,
- RNA Polymerase II Promoter Escape,
- Peptide chain elongation,
- Eukaryotic Translation Termination,
- Nonsense-Mediated Decay,
- Formation of RNA Pol II elongation complex,
- Ribosomal scanning and start codon recognition,
- Elongation arrest and recovery,
- mRNA Processing
2 Cross References
| Identifier |
Source . Name |
Subject . Primary Identifier |
|---|---|---|
| 44251 | NCBI Entrez Gene identifiers | FBgn0261602 |
| 68919 | BioGRID | FBgn0261602 |
10 Data Sets
| Name | URL |
|---|---|
| FlyBase data set for Drosophila melanogaster | |
| Swiss-Prot data set | http://ca.expasy.org/sprot |
| Drosophila 12 Genomes Consortium homology | |
| GenomeRNAi data set | |
| TreeFam data set | |
| Panther data set | |
| IntAct interactions data set | |
| BioGRID interaction data set | http://www.thebiogrid.org/downloads.php |
| GO Annotation from FlyBase | |
| FlyBase fasta data set for Drosophila melanogaster |
41 RNAi Results
| Screen | Gene | Phenotype | Score | Conditions | PubMed ID |
|---|---|---|---|---|---|
| Lipid storage | RpL8 | Increased lipid droplet area | 2.337472503 | 19067489 | |
| Lipid storage | RpL8 | Increased lipid droplet area | 2.019849313 | 19067489 | |
| Lipid storage | RpL8 | none | 1.325405774 | 19067489 | |
| Lipid storage | RpL8 | none | 1.948651145 | 19067489 | |
| Drosophila C virus infection | RpL8 | Drosophila C virus replication down | np | 17040126 | |
| Cytokinesis regulation | RpL8 | Binucleate cells | weak | 15547975 | |
| Intracellular Listeria monocytogenes infection | RpL8 | Increased GFP protein expression | strong | 16020693 | |
| Drosophila C virus infection | RpL8 | Drosophila C virus infection reduced | np | 15713840 | |
| Hedgehog signaling | RpL8 | Decreased Hedgehog reporter activity | -2.51 | 16311596 | |
| Hedgehog signaling | RpL8 | Decreased Hedgehog reporter activity | -2.68 | 16311596 | |
| Constitutive protein secretion and Golgi organization (1) | RpL8 | Decreased horseradish peroxidase protein expression | sp | 16452979 | |
| Constitutive protein secretion and Golgi organization (1) | RpL8 | Decreased horseradish peroxidase protein expression | sp | 16452979 | |
| Cell size and cell-cycle regulation (1) | RpL8 | Increased G1 DNA content, decreased G2 DNA content, decreased G1 cell size, decreased viability | sp | 16496002 | |
| Cell size and cell-cycle regulation (1) | RpL8 | none | sp | 16496002 | |
| Cell size and cell-cycle regulation (1) | RpL8 | none | sp | 16496002 | |
| Cell size and cell-cycle regulation (1) | RpL8 | Increased G1 DNA content, decreased viability, decreased cytokinesis | sp | 16496002 | |
| Cell size and cell-cycle regulation (2) | RpL8 | Decreased viability | 0.697 | 16496002 | |
| Cell size and cell-cycle regulation (2) | RpL8 | Decreased viability | 0.751 | 16496002 | |
| Cell size and cell-cycle regulation (3) | RpL8 | none | 419 | 16496002 | |
| Cell size and cell-cycle regulation (3) | RpL8 | none | 443 | 16496002 | |
| Lipid storage | RpL8 | More dispersed droplets | strong (but ribosomal) | 18408709 | |
| Muscle morphogenesis and function (1) | RpL8 | Lethal | np | 20220848 | |
| Muscle morphogenesis and function (2) | RpL8 | Wing posture / locomotion / ability to fly defect or lethal / semi-lethal | np | 20220848 | |
| Muscle morphogenesis and function (3) | RpL8 | Spotty (discontinuous) Z-line | np | 20220848 | |
| Heat nociception (1) | RpL8 | Lethal | -1.17 | 21074052 | |
| Heart development and function (1) | RpL8 | Adult lethal | 0.5 | 20371351 | |
| Serratia marcescens infection (1) | RpL8 | none | 0.267605633802816 | 19520911 | |
| Notch pathway regulation (4) | RpL8 | Completely lethal (pupal) | sp | 19363474 | |
| Hh pathway regulation | RpL8 | Downregulation of Hh pathway | -0.618078473550773 | 17903264 | |
| Hh pathway regulation | RpL8 | Downregulation of Hh pathway | -0.556547226933904 | 17903264 |
