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Gene : 5-HT1B D. melanogaster

DB identifier  ? FBgn0263116 Secondary Identifier  ? CG15113
Name  ? 5-hydroxytryptamine (serotonin) receptor 1B Source  FlyBase
  • synonyms:
  • Drosophila serotonin receptor 1B,
  • Serotonin receptor 1B,
  • 5-HT[[1BDro]],
  • CG30126,
  • 5HT-dro2B,
  • 5-HT[[dro2B]],
  • FBgn0263116,
  • FBgn0004572,
  • Serotonin receptor 2B,
  • 5-HT[[1B]]DRO,
  • 5htdro2b,
  • 5-HT[1B]Dro,
  • 5HT-dro[[2B]],
  • FBan0030126,
  • 5-HT[[1B]],
  • FBgn0050126,
  • 5HT-R2B,
  • Dm5HTdro2B,
  • DRO2B,
  • 5-HT-dro2B,
  • 5HT1B,
  • FBan0015113,
  • d5-HT1B,
  • 5-HT1BDro,
  • CG15113

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12 Alleles

DB identifier Symbol Allele Class Organism
FBal0202483 5-HT1B[GD13681]   Drosophila melanogaster
FBal0257195 5-HT1B[HMS00300]   Drosophila melanogaster
FBal0198375 5-HT1B[MB05181]   Drosophila melanogaster
FBal0259908 5-HT1B[KK112342]   Drosophila melanogaster
FBal0260078 5-HT1B[KK115609]   Drosophila melanogaster
FBal0276979 5-HT1B[MI05213]   Drosophila melanogaster
FBal0285935 5-HT1B[DeltaIII-V] amorphic allele - molecular evidence Drosophila melanogaster
FBal0198589 5-HT1B[GD617]   Drosophila melanogaster
FBal0198590 5-HT1B[GD17040]   Drosophila melanogaster
FBal0194588 5-HT1B[Scer\UAS.cYa]   Drosophila melanogaster
FBal0194589 5-HT1B[dsRNA.Scer\UAS]   Drosophila melanogaster
FBal0219860 5-HT1B[JF01851]   Drosophila melanogaster

4 Clones

Secondary Identifier DB identifier
IP03495 FBcl0303837
IP03395 FBcl0339541
IP03295 FBcl0346476
IP20237 FBcl0702388

11 Exons

DB identifier Symbol
FBgn0263116:11 5-HT1B:11
FBgn0263116:10 5-HT1B:10
FBgn0263116:9 5-HT1B:9
FBgn0263116:8 5-HT1B:8
FBgn0263116:7 5-HT1B:7
FBgn0263116:6 5-HT1B:6
FBgn0263116:4 5-HT1B:4
FBgn0263116:3 5-HT1B:3
FBgn0263116:2 5-HT1B:2
FBgn0263116:5 5-HT1B:5
FBgn0263116:1 5-HT1B:1

3 Transcripts

DB identifier Gene
FBtr0086599 5-HT1B
FBtr0330055 5-HT1B
FBtr0330056 5-HT1B

6 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0086599-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0330055-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0330056-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0086599-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0330055-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0330056-3-prime-utr Drosophila melanogaster

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1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
37191 NCBI Entrez Gene identifiers FBgn0263116

8 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  

0 Expression Scores

11 Introns

DB identifier
Organism . Name
intron_FBgn0263116:11_FBgn0263116:10 Drosophila melanogaster
intron_FBgn0263116:10_FBgn0263116:9 Drosophila melanogaster
intron_FBgn0263116:9_FBgn0263116:8 Drosophila melanogaster
intron_FBgn0263116:8_FBgn0263116:7 Drosophila melanogaster
intron_FBgn0263116:7_FBgn0263116:6 Drosophila melanogaster
intron_FBgn0263116:6_FBgn0263116:4 Drosophila melanogaster
intron_FBgn0263116:4_FBgn0263116:3 Drosophila melanogaster
intron_FBgn0263116:3_FBgn0263116:2 Drosophila melanogaster
intron_FBgn0263116:6_FBgn0263116:5 Drosophila melanogaster
intron_FBgn0263116:5_FBgn0263116:3 Drosophila melanogaster
intron_FBgn0263116:3_FBgn0263116:1 Drosophila melanogaster

33 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage 5-HT1B Decreased lipid droplet area -2.467216353   19067489
Lipid storage 5-HT1B Decreased lipid droplet area -2.0811576   19067489
Lipid storage 5-HT1B none -2.713917497   19067489
Lipid storage 5-HT1B none 2.605120068   19067489
Hedgehog signaling 5-HT1B Decreased Hedgehog reporter activity -2.93   16311596
Constitutive protein secretion and Golgi organization (1) 5-HT1B Decreased horseradish peroxidase protein expression sp   16452979
Ca2+ channel regulation 5-HT1B Decreased Ca2+ influx 4   16645049
Muscle morphogenesis and function (1) 5-HT1B none np   20220848
Muscle morphogenesis and function (1) 5-HT1B none np   20220848
Muscle morphogenesis and function (1) 5-HT1B none np   20220848
Heat nociception (1) 5-HT1B none -0.82   21074052
Heat nociception (1) 5-HT1B Lethal -1.17   21074052
Heat nociception (1) 5-HT1B Lethal -1.17   21074052
Heat nociception (1) 5-HT1B Lethal -1.17   21074052
Heat nociception (1) 5-HT1B Lethal -1.17   21074052
Heat nociception (1) 5-HT1B Lethal -1.17   21074052
Heart development and function (1) 5-HT1B none 1   20371351
Serratia marcescens infection (1) 5-HT1B none 1.08641975308641   19520911
Serratia marcescens infection (1) 5-HT1B none -0.395061728395061   19520911
Serratia marcescens infection (1) 5-HT1B none -5.08064516129032   19520911
Notch pathway regulation (4) 5-HT1B none 0   19363474
Notch pathway regulation (4) 5-HT1B none 0   19363474
Notch pathway regulation (4) 5-HT1B none 0   19363474
Adiposity regulation (1) 5-HT1B none 0.654   20074523
Adiposity regulation (1) 5-HT1B none -0.059   20074523
Adiposity regulation (1) 5-HT1B none 0.054   20074523
RTK-Ras-ERK pathway regulation (1) 5-HT1B Increased ERK phosphorylation after EGF stimulation 2.56 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) 5-HT1B none 0.11 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) 5-HT1B none -0.49 30 minutes sSpitz stimulation 22028469
RTK-Ras-ERK pathway regulation (2) 5-HT1B none 0.19 10 minutes sSpitz stimulation 22028469

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