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Gene : SNF1A D. melanogaster

DB identifier  ? FBgn0023169 Secondary Identifier  ? CG3051
Name  ? SNF1A/AMP-activated protein kinase Source  FlyBase
  • synonyms:
  • dAMPKa,
  • AMPKalpha,
  • G protein-coupled receptor kinase 4,
  • 5'monophosphate-activated kinase,
  • CG3051,
  • FBgn0004836,
  • dAMPKalpha,
  • AMP-dependent kinase,
  • EG:132E8.2,
  • AMP-activated protein kinase,
  • FBan0003051,
  • AMP-activated kinase,
  • FBgn0029574,
  • Gprk-4,
  • snf1a,
  • adenosine monophosphate-activated protein kinase,
  • Gprk4,
  • DmAMPK alpha,
  • AMPK,
  • FBgn0023169

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33 Alleles

DB identifier Symbol Allele Class Organism
FBal0241419 SNF1A[1] amorphic allele - genetic evidence Drosophila melanogaster
FBal0241420 SNF1A[2] amorphic allele - genetic evidence Drosophila melanogaster
FBal0241421 SNF1A[3] amorphic allele - genetic evidence Drosophila melanogaster
FBal0241422 SNF1A[Scer\UAS.cMa]   Drosophila melanogaster
FBal0241423 SNF1A[Scer\UAS.T:Disc\RFP-mCherry]   Drosophila melanogaster
FBal0246370 SNF1A[Delta39]   Drosophila melanogaster
FBal0246371 SNF1A[Scer\UAS.cBa]   Drosophila melanogaster
FBal0246372 SNF1A[K56R.Scer\UAS]   Drosophila melanogaster
FBal0265789 SNF1A[Scer\UAS.cKa]   Drosophila melanogaster
FBal0246589 SNF1A[unspecified]   Drosophila melanogaster
FBal0213116 SNF1A[G505]   Drosophila melanogaster
FBal0213117 SNF1A[D1]   Drosophila melanogaster
FBal0213119 SNF1A[WT.Scer\UAS]   Drosophila melanogaster
FBal0213118 SNF1A[D2]   Drosophila melanogaster
FBal0213120 SNF1A[KR.Scer\UAS]   Drosophila melanogaster
FBal0213121 SNF1A[TD.Scer\UAS]   Drosophila melanogaster
FBal0248127 SNF1A[HMS00362]   Drosophila melanogaster
FBal0141548 SNF1A[cPa]   Drosophila melanogaster
FBal0141549 SNF1A[a.cPa]   Drosophila melanogaster
FBal0262496 SNF1A[GL00004]   Drosophila melanogaster
FBal0193417 SNF1A[D39]   Drosophila melanogaster
FBal0246972 SNF1A[DeltaC.Scer\UAS]   Drosophila melanogaster
FBal0246973 SNF1A[DeltaC.Scer\UAS.T:Disc\RFP-mCherry]   Drosophila melanogaster
FBal0246974 SNF1A[Scer\UAS.T:Avic\GFP]   Drosophila melanogaster
FBal0241312 SNF1A[T184D.Scer\UAS]   Drosophila melanogaster
FBal0246548 SNF1A[K57A.Scer\UAS]   Drosophila melanogaster
FBal0287066 SNF1A[Scer\UAS.ORF]   Drosophila melanogaster
FBal0287067 SNF1A[Scer\UAS.ORF.T:Ivir\HA1]   Drosophila melanogaster
FBal0208455 SNF1A[GD736]   Drosophila melanogaster
FBal0219937 SNF1A[JF01951]   Drosophila melanogaster

106 Clones

Secondary Identifier DB identifier
AT07322 FBcl0014939
EK172806 FBcl0069168
EK237749 FBcl0069306
EK111057 FBcl0069318
EK268420 FBcl0069386
EK060846 FBcl0069460
EK179357 FBcl0069834
GH04642 FBcl0128125
GH02831 FBcl0128127
GH12837 FBcl0128133
GH05909 FBcl0128165
GH07170 FBcl0128201
GH06150 FBcl0128207
GH10370 FBcl0128227
GH03262 FBcl0128245
GH25958 FBcl0128269
GH20217 FBcl0128285
GH17718 FBcl0128293
GH08222 FBcl0128327
GH16225 FBcl0128333
GH02732 FBcl0128403
GH13962 FBcl0128425
GH11306 FBcl0128459
GH12596 FBcl0128567
GM07749 FBcl0139581
GM10593 FBcl0139591
LD10636 FBcl0159973
LD05233 FBcl0160049
LD14193 FBcl0160116
LD21307 FBcl0175216

6 Exons

DB identifier Symbol
FBgn0023169:1 SNF1A:1
FBgn0023169:3 SNF1A:3
FBgn0023169:5 SNF1A:5
FBgn0023169:2 SNF1A:2
FBgn0023169:6 SNF1A:6
FBgn0023169:4 SNF1A:4

3 Transcripts

DB identifier Gene
FBtr0070216 SNF1A
FBtr0070217 SNF1A
FBtr0070218 SNF1A

6 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0070216-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0070217-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0070218-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0070216-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0070217-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0070218-3-prime-utr Drosophila melanogaster

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2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
43904 NCBI Entrez Gene identifiers FBgn0023169
68705 BioGRID FBgn0023169

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
TrEMBL data set http://www.ebi.ac.uk/trembl/
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0023169 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 984.0
FBgn0023169 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 1292.0
FBgn0023169 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 750.0
FBgn0023169 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 1055.0
FBgn0023169 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 886.0
FBgn0023169 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 418.0
FBgn0023169 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 741.0
FBgn0023169 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 503.0
FBgn0023169 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 1081.0
FBgn0023169 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 758.0
FBgn0023169 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 1133.0
FBgn0023169 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 355.0
FBgn0023169 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 974.0
FBgn0023169 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 1300.0
FBgn0023169 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 1465.0
FBgn0023169 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 752.0
FBgn0023169 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 521.0
FBgn0023169 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 432.0
FBgn0023169 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 1274.0
FBgn0023169 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 986.0
FBgn0023169 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 850.0
FBgn0023169 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 937.0
FBgn0023169 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 1290.0
FBgn0023169 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 751.0
FBgn0023169 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 561.0
FBgn0023169 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 1491.0
FBgn0023169 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 758.0
FBgn0023169 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 579.0
FBgn0023169 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 679.0
FBgn0023169 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 703.0

5 Introns

DB identifier
Organism . Name
intron_FBgn0023169:1_FBgn0023169:3 Drosophila melanogaster
intron_FBgn0023169:3_FBgn0023169:5 Drosophila melanogaster
intron_FBgn0023169:2_FBgn0023169:6 Drosophila melanogaster
intron_FBgn0023169:1_FBgn0023169:4 Drosophila melanogaster
intron_FBgn0023169:4_FBgn0023169:6 Drosophila melanogaster

39 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage SNF1A none 0.48003646   19067489
Cell cycle regulation (1) SNF1A Increased S DNA content, increased G2/M DNA content, all mitotic defects, centrosome defects sp   15616552
Cell cycle regulation (2) SNF1A Increased S DNA content or increased number of aneuploid cells, increased G2 DNA content np   15616552
Cell size and cell-cycle regulation (1) SNF1A none sp   16496002
Cell size and cell-cycle regulation (1) SNF1A none sp   16496002
Cell size and cell-cycle regulation (1) SNF1A none sp   16496002
Cell size and cell-cycle regulation (2) SNF1A none 1.156   16496002
Cell size and cell-cycle regulation (3) SNF1A none 459   16496002
Cell size and cell-cycle regulation (4) SNF1A Increased number of mitotic cells 1.1   16496002
Candida albicans phagocytosis (1) SNF1A Decreased Candida albicans phagocytosis np   16336044
Candida albicans phagocytosis (2) SNF1A none 46   16336044
Candida albicans phagocytosis (3) SNF1A Decreased latex beads phagocytosis 34   16336044
DFoxO signaling SNF1A Decreased dFoxO reporter activity 0.002   18815370
Combinatorial effect with methyl methanesulphonate (1) SNF1A none sp   19543366
Combinatorial effect with methyl methanesulphonate (2) SNF1A none sp   19543366
Muscle morphogenesis and function (1) SNF1A Lethal np   20220848
Muscle morphogenesis and function (1) SNF1A Lethal np   20220848
Muscle morphogenesis and function (2) SNF1A Wing posture / locomotion / ability to fly defect or lethal / semi-lethal np   20220848
Heat nociception (1) SNF1A none 0.83   21074052
Heart development and function (1) SNF1A none 1   20371351
Serratia marcescens infection (1) SNF1A none -0.36734693877551   19520911
Notch pathway regulation (4) SNF1A none 0   19363474
PGN-induced dJNK phosphorylation SNF1A Increased P-JNK protein expression with PGN 3.24 60 min PGN induction 19893628
Akt-TOR pathway negative feedback regulation SNF1A Decreased dAkt phosphorylation after insulin stimulation -2.7 10 min insulin stimulation 20585550
Adiposity regulation (1) SNF1A none -0.152   20074523
Blood cell homeostasis regulation (1) SNF1A none np   20540764
Blood cell homeostasis regulation (2) SNF1A Increased melanotic mass formation np   20540764
Blood cell homeostasis regulation (3) SNF1A none 0   20540764
Blood cell homeostasis regulation (4) SNF1A none 0   20540764
Blood cell homeostasis regulation (5) SNF1A none 0   20540764

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