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Gene : S6k D. melanogaster

DB identifier  ? FBgn0015806 Secondary Identifier  ? CG10539
Name  ? RPS6-p70-protein kinase Source  FlyBase
  • synonyms:
  • S6kinase,
  • p70 S6 Kinase,
  • FBgn0010455,
  • S6k|S6K,
  • fs(3)07084,
  • Dp70S6k,
  • p70[S6 kinase],
  • dps6k,
  • p70[S6K],
  • p70[S6kinase],
  • 10539,
  • FBan0010539,
  • S6K1,
  • S6-kinase,
  • S6K,
  • 7084,
  • S6 Kinase,
  • dS6 kinase,
  • s6k11,
  • p70S6K,
  • CG10539,
  • p70 S6K,
  • DS6K,
  • FBgn0011551,
  • p70 ribosomal S6 kinase,
  • ribosomal S6 protein kinase,
  • p70/S6K,
  • ribosomal protein S6 kinase,
  • Dp70[s6k],
  • FBgn0015806,
  • l(3)07084

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31 Alleles

DB identifier Symbol Allele Class Organism
FBal0257077 S6k[HMS00034]   Drosophila melanogaster
FBal0265716 S6k[Scer\UAS.cCa]   Drosophila melanogaster
FBal0265717 S6k[Scer\UAS.T:Zzzz\FLAG]   Drosophila melanogaster
FBal0265718 S6k[Scer\UAS.T:Avic\GFP-YFP.Venus]   Drosophila melanogaster
FBal0281415 S6k[HMJ02231]   Drosophila melanogaster
FBal0211732 S6k[CC01583]   Drosophila melanogaster
FBal0181738 S6k[f07622]   Drosophila melanogaster
FBal0004707 S6k[07084]   Drosophila melanogaster
FBal0286502 S6k[Scer\UAS.ORF]   Drosophila melanogaster
FBal0260674 S6k[NIG.10539R]   Drosophila melanogaster
FBal0286503 S6k[Scer\UAS.ORF.T:Ivir\HA1]   Drosophila melanogaster
FBal0278767 S6k[GL01327]   Drosophila melanogaster
FBal0103998 S6k[alphaTub.PM]   Drosophila melanogaster
FBal0175966 S6k[dsRNA.cSa]   Drosophila melanogaster
FBal0103995 S6k[unspecified]   Drosophila melanogaster
FBal0103996 S6k[l-1]   Drosophila melanogaster
FBal0261435 S6k[CPTI003751]   Drosophila melanogaster
FBal0058294 S6k[cSa.T:Hsap\MYC]   Drosophila melanogaster
FBal0152233 S6k[cZa.T:Ivir\HA1]   Drosophila melanogaster
FBal0141554 S6k[KQ.Scer\UAS]   Drosophila melanogaster
FBal0103997 S6k[Scer\UAS.cMa]   Drosophila melanogaster
FBal0120644 S6k[Scer\UAS.cWa]   Drosophila melanogaster
FBal0141553 S6k[STDE.Scer\UAS]   Drosophila melanogaster
FBal0141552 S6k[STDETE.Scer\UAS]   Drosophila melanogaster
FBal0141551 S6k[TE.Scer\UAS]   Drosophila melanogaster
FBal0208434 S6k[GD6646]   Drosophila melanogaster
FBal0279269 S6k[HMS02267]   Drosophila melanogaster
FBal0247992 S6k[+t14.8]   Drosophila melanogaster
FBal0228969 S6k[NP4439]   Drosophila melanogaster
FBal0228970 S6k[DG08212]   Drosophila melanogaster

149 Clones

Secondary Identifier DB identifier
IP06441 FBcl0349479
EC13273 FBcl0064787
EK268613 FBcl0068100
EK215234 FBcl0068500
EK194263 FBcl0068520
EK307358 FBcl0068596
EK106605 FBcl0068614
EK066317 FBcl0068634
EK219740 FBcl0068648
EK206313 FBcl0068666
EK228332 FBcl0068678
EK105328 FBcl0068696
EK098621 FBcl0068714
EK223417 FBcl0068732
EK294512 FBcl0068748
EK109359 FBcl0068780
EK004036 FBcl0068796
EK147037 FBcl0068814
EK177101 FBcl0068830
EK249538 FBcl0068848
EK004026 FBcl0068870
EK160231 FBcl0068888
EK009936 FBcl0068910
EK067501 FBcl0068926
EK119418 FBcl0068942
EK144318 FBcl0068978
EK116740 FBcl0069020
EK252041 FBcl0069036
EK100405 FBcl0069054
EK011423 FBcl0069072

11 Exons

DB identifier Symbol
FBgn0015806:11 S6k:11
FBgn0015806:10 S6k:10
FBgn0015806:9 S6k:9
FBgn0015806:8 S6k:8
FBgn0015806:7 S6k:7
FBgn0015806:6 S6k:6
FBgn0015806:5 S6k:5
FBgn0015806:4 S6k:4
FBgn0015806:3 S6k:3
FBgn0015806:2 S6k:2
FBgn0015806:1 S6k:1

2 Transcripts

DB identifier Gene
FBtr0333264 S6k
FBtr0077114 S6k

4 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0077114-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0333264-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0077114-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0333264-3-prime-utr Drosophila melanogaster

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54 Pathways

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
38654 NCBI Entrez Gene identifiers FBgn0015806
64114 BioGRID FBgn0015806

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
TrEMBL data set http://www.ebi.ac.uk/trembl/
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0015806 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 2849.0
FBgn0015806 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 1790.0
FBgn0015806 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 2655.0
FBgn0015806 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 1817.0
FBgn0015806 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 2617.0
FBgn0015806 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 2184.0
FBgn0015806 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 6407.0
FBgn0015806 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 3324.0
FBgn0015806 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 2343.0
FBgn0015806 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 3397.0
FBgn0015806 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 5360.0
FBgn0015806 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 2336.0
FBgn0015806 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 2031.0
FBgn0015806 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 1257.0
FBgn0015806 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 2474.0
FBgn0015806 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 1568.0
FBgn0015806 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 4691.0
FBgn0015806 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 4102.0
FBgn0015806 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 2302.0
FBgn0015806 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 2529.0
FBgn0015806 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 3641.0
FBgn0015806 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 2012.0
FBgn0015806 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 2630.0
FBgn0015806 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 5363.0
FBgn0015806 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 4806.0
FBgn0015806 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 3813.0
FBgn0015806 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 1705.0
FBgn0015806 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 2726.0
FBgn0015806 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 2148.0
FBgn0015806 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 2564.0

10 Introns

DB identifier
Organism . Name
intron_FBgn0015806:11_FBgn0015806:10 Drosophila melanogaster
intron_FBgn0015806:10_FBgn0015806:9 Drosophila melanogaster
intron_FBgn0015806:9_FBgn0015806:8 Drosophila melanogaster
intron_FBgn0015806:8_FBgn0015806:7 Drosophila melanogaster
intron_FBgn0015806:7_FBgn0015806:6 Drosophila melanogaster
intron_FBgn0015806:6_FBgn0015806:5 Drosophila melanogaster
intron_FBgn0015806:5_FBgn0015806:4 Drosophila melanogaster
intron_FBgn0015806:4_FBgn0015806:3 Drosophila melanogaster
intron_FBgn0015806:3_FBgn0015806:2 Drosophila melanogaster
intron_FBgn0015806:3_FBgn0015806:1 Drosophila melanogaster

35 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Cell size regulation S6k none -0.81   19216764
Lipid storage S6k none 1.348022649   19067489
Lipid storage S6k none 2.726643499   19067489
ERK signaling S6k ERK activation increased moderate   17086199
Cell morphology S6k Morphology np   14527345
Cell cycle regulation (1) S6k Increased G1 DNA content, decreased cell size sp   15616552
Cell cycle regulation (2) S6k Increased G1 DNA content, decreased cell size np   15616552
Cell size and cell-cycle regulation (1) S6k none sp   16496002
Cell size and cell-cycle regulation (1) S6k Decreased G2 DNA content sp   16496002
Cell size and cell-cycle regulation (1) S6k none sp   16496002
Cell size and cell-cycle regulation (2) S6k none 1.248   16496002
Cell size and cell-cycle regulation (3) S6k none 467   16496002
Candida albicans phagocytosis (1) S6k Decreased Candida albicans phagocytosis np   16336044
Candida albicans phagocytosis (2) S6k Decreased Escherichia coli phagocytosis 32   16336044
Candida albicans phagocytosis (3) S6k none 56   16336044
Mitochondrial biogenesis and function S6k Increased mitochondrial citrate synthase activity 1.202   18042644
Combinatorial effect with methyl methanesulphonate (2) S6k Synthetic lethal with methyl methanesulphonate sp   19543366
Heat nociception (1) S6k none -1.17   21074052
Heart development and function (1) S6k none 1   20371351
Serratia marcescens infection (1) S6k none 0.357142857142857   19520911
Notch pathway regulation (4) S6k Bristle morphology defects 7   19363474
Akt-TOR pathway negative feedback regulation S6k Increased dAkt phosphorylation 3.6 without insulin stimulation 20585550
Actin organization and cell morphology (1) S6k none np   19265526
Actin organization and cell morphology (2) S6k Altered cell morphology np   19265526
Actin organization and cell morphology (3) S6k none np   19265526
Actin organization and cell morphology (4) S6k none np   19265526
Actin organization and cell morphology (5) S6k none np   19265526
Actin organization and cell morphology (6) S6k none np   19265526
RTK-Ras-ERK pathway regulation (1) S6k none -1.15 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) S6k none -0.91 0 minutes EGF stimulation 22028469

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