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Gene : RpS6 D. melanogaster

DB identifier  ? FBgn0261592 Secondary Identifier  ? CG10944
Name  ? Ribosomal protein S6 Source  FlyBase
  • synonyms:
  • hen,
  • FBgn0004922,
  • air[8],
  • FBan0010944,
  • l(1)air[8],
  • lethal-(1)-haemocytes enlarged,
  • CG10944,
  • l(1)hen,
  • RPS6,
  • FBgn0002584,
  • M(1)7C,
  • FBgn0261592,
  • lethal-aberrant-immune-response-8,
  • M(1)7BC,
  • Minute (1) 7BC,
  • FBgn0002585,
  • hemocytes enlarged,
  • DS6,
  • S6 ribosomal protein,
  • (Rp)S6,
  • Rp S6,
  • anon-WO02059370.61,
  • FBgn0005276,
  • Minute,
  • FBgn0004371,
  • pp30,
  • FBgn0065997,
  • air8,
  • S6,
  • lethal(1)aberrant immune response[8],
  • l(1)air8,
  • FBgn0004388,
  • FBgn0004405,
  • ribosomal protein S6

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14 Alleles

DB identifier Symbol Allele Class Organism
FBal0282874 RpS6[Scer\UAS.T:Disc\RFP-mRFP]   Drosophila melanogaster
FBal0286417 RpS6[Scer\UAS.ORF]   Drosophila melanogaster
FBal0286418 RpS6[Scer\UAS.ORF.T:Ivir\HA1]   Drosophila melanogaster
FBal0268399 RpS6[Scer\UAS.cLa]   Drosophila melanogaster
FBal0268400 RpS6[dsRNA.Sym.Scer\UAS]   Drosophila melanogaster
FBal0030172 RpS6[WG1288] loss of function allele Drosophila melanogaster
FBal0030171 RpS6[hen1]   Drosophila melanogaster
FBal0030173 RpS6[air8] loss of function allele Drosophila melanogaster
FBal0052111 RpS6[2rev]   Drosophila melanogaster
FBal0270667 RpS6[NIG.10944R]   Drosophila melanogaster
FBal0214761 RpS6[GD16544]   Drosophila melanogaster
FBal0214762 RpS6[GD7137]   Drosophila melanogaster
FBal0248174 RpS6[HMS00413]   Drosophila melanogaster
FBal0235071 RpS6[KK107652]   Drosophila melanogaster

380 Clones

Secondary Identifier DB identifier
UUGC0165 FBcl0001287
UUGC0414 FBcl0001341
UUGC0416 FBcl0001359
UUGC0420 FBcl0001407
ESG0111a.B21_D10 FBcl0001588
ESG0118d.B21_F03 FBcl0002169
UUGC0794 FBcl0004495
ESG0114c.B21_H08 FBcl0007099
ESG0113c.B21_G01 FBcl0007651
AT19484 FBcl0014907
AT25178 FBcl0014951
AT23290 FBcl0014963
AT27174 FBcl0016131
bs60d02 FBcl0056007
EK117539 FBcl0061970
EK252020 FBcl0062370
EK123003 FBcl0062614
EC02024 FBcl0064409
EC25653 FBcl0064485
EC23816 FBcl0064489
EC30116 FBcl0064493
EC30280 FBcl0070723
EK195457 FBcl0089580
EN11148 FBcl0092919
EN17846 FBcl0093023
EN01428 FBcl0093025
EN09854 FBcl0093027
EN11725 FBcl0093029
EN04957 FBcl0093117
EN17843 FBcl0093195

4 Exons

DB identifier Symbol
FBgn0261592:4 RpS6:4
FBgn0261592:2 RpS6:2
FBgn0261592:1 RpS6:1
FBgn0261592:3 RpS6:3

2 Transcripts

DB identifier Gene
FBtr0071135 RpS6
FBtr0071136 RpS6

4 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0071135-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0071136-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0071135-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0071136-3-prime-utr Drosophila melanogaster

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75 Pathways

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
31700 NCBI Entrez Gene identifiers FBgn0261592
58174 BioGRID FBgn0261592

10 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  

0 Expression Scores

3 Introns

DB identifier
Organism . Name
intron_FBgn0261592:4_FBgn0261592:2 Drosophila melanogaster
intron_FBgn0261592:2_FBgn0261592:1 Drosophila melanogaster
intron_FBgn0261592:3_FBgn0261592:1 Drosophila melanogaster

24 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage RpS6 Increased lipid droplet area 4.447277326   19067489
Lipid storage RpS6 Increased lipid droplet area 0.726340546   19067489
Lipid storage RpS6 Increased lipid droplet area 1.225438887   19067489
Lipid storage RpS6 Increased lipid droplet area 2.651270505   19067489
Drosophila C virus infection RpS6 Drosophila C virus replication down np   17040126
Cytokinesis regulation RpS6 Binucleate cells with decreased viability medium   15547975
Intracellular Listeria monocytogenes infection RpS6 Increased GFP protein expression moderate   16020693
Drosophila C virus infection RpS6 Drosophila C virus infection reduced np   15713840
Hedgehog signaling RpS6 Decreased Hedgehog reporter activity -2.87   16311596
Constitutive protein secretion and Golgi organization (1) RpS6 Decreased horseradish peroxidase protein expression sp   16452979
Cell size and cell-cycle regulation (1) RpS6 Increased G1 DNA content, decreased G2 DNA content, decreased viability, decreased cytokinesis sp   16496002
Cell size and cell-cycle regulation (2) RpS6 none 1.048   16496002
Cell size and cell-cycle regulation (3) RpS6 none 446   16496002
Candida albicans phagocytosis (1) RpS6 none np   16336044
Lipid storage RpS6 More dispersed droplets strong (but ribosomal)   18408709
Combinatorial effect with methyl methanesulphonate (2) RpS6 Synthetic lethal with methyl methanesulphonate sp   19543366
Mutant human huntingtin aggregation RpS6 Decreased mutant human huntingtin aggregation <= -2   19789644
Hh pathway regulation RpS6 Downregulation of Hh pathway -0.501144770530667   17903264
RTK-Ras-ERK pathway regulation (1) RpS6 none 0.72 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) RpS6 Decreased ERK phosphorylation after EGF stimulation -3.62 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) RpS6 Increased ERK phosphorylation after sSpitz and EGF stimulation 1.87 10 minutes sSpitz stimulation 22028469
RTK-Ras-ERK pathway regulation (2) RpS6 Increased ERK phosphorylation after sSpitz and EGF stimulation 4.11 30 minutes sSpitz stimulation 22028469
Hippo pathway regulation RpS6 none -1.87   23263283
Glycosylation regulation (1) RpS6 Decreased Chp protein expression np   21203496

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