Genomics
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14 Alleles
DB identifier | Symbol | Allele Class | Organism |
---|---|---|---|
FBal0282874 | RpS6[Scer\UAS.T:Disc\RFP-mRFP] | Drosophila melanogaster | |
FBal0286417 | RpS6[Scer\UAS.ORF] | Drosophila melanogaster | |
FBal0286418 | RpS6[Scer\UAS.ORF.T:Ivir\HA1] | Drosophila melanogaster | |
FBal0268399 | RpS6[Scer\UAS.cLa] | Drosophila melanogaster | |
FBal0268400 | RpS6[dsRNA.Sym.Scer\UAS] | Drosophila melanogaster | |
FBal0030172 | RpS6[WG1288] | loss of function allele | Drosophila melanogaster |
FBal0030171 | RpS6[hen1] | Drosophila melanogaster | |
FBal0030173 | RpS6[air8] | loss of function allele | Drosophila melanogaster |
FBal0052111 | RpS6[2rev] | Drosophila melanogaster | |
FBal0270667 | RpS6[NIG.10944R] | Drosophila melanogaster | |
FBal0214761 | RpS6[GD16544] | Drosophila melanogaster | |
FBal0214762 | RpS6[GD7137] | Drosophila melanogaster | |
FBal0248174 | RpS6[HMS00413] | Drosophila melanogaster | |
FBal0235071 | RpS6[KK107652] | Drosophila melanogaster |
380 Clones
4 Exons
DB identifier | Symbol |
---|---|
FBgn0261592:4 | RpS6:4 |
FBgn0261592:2 | RpS6:2 |
FBgn0261592:1 | RpS6:1 |
FBgn0261592:3 | RpS6:3 |
4 UTRs
Class | DB identifier |
Organism . Name |
---|---|---|
FivePrimeUTR | FBtr0071135-5-prime-utr | Drosophila melanogaster |
FivePrimeUTR | FBtr0071136-5-prime-utr | Drosophila melanogaster |
ThreePrimeUTR | FBtr0071135-3-prime-utr | Drosophila melanogaster |
ThreePrimeUTR | FBtr0071136-3-prime-utr | Drosophila melanogaster |
Other
75 Pathways
- SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs,
- Regulation of Rheb GTPase activity by AMPK,
- SRP-dependent cotranslational protein targeting to membrane,
- mRNA Capping,
- RNA Polymerase II Transcription Initiation,
- RNA Polymerase II Transcription Elongation,
- PI3K Cascade,
- Release of eIF4E,
- Metabolism of RNA,
- IRS activation,
- Nonsense-Mediated Decay,
- DINR-mediated activation,
- IGF1R signaling cascade,
- TOR signaling pathway,
- RNA Polymerase II Pre-transcription Events,
- RNA Polymerase II Transcription Termination,
- SLBP independent Processing of Histone Pre-mRNAs,
- IRS-related events,
- Insulin receptor mediated signaling,
- RNA Polymerase II Transcription Pre-Initiation And Promoter Opening,
- Transport of Mature mRNA Derived from an Intronless Transcript,
- Eukaryotic Translation Termination,
- Insulin receptor signalling cascade,
- RNA Pol II CTD phosphorylation and interaction with CE,
- Recycling of eIF2:GDP,
- Energy dependent regulation of mTOR by LKB1-AMPK,
- RNA Polymerase II Transcription,
- IRS-mediated signalling,
- Processing of Capped Intron-Containing Pre-mRNA,
- Transport of the SLBP independent Mature mRNA,
- S6K1-mediated signalling,
- Insulin receptor recycling,
- Post-Elongation Processing of Intronless pre-mRNA,
- Elongation arrest and recovery,
- Gene Expression,
- S6K1 signalling,
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R),
- GTP hydrolysis and joining of the 60S ribosomal subunit,
- Peptide chain elongation,
- Signaling Pathways,
- IRS-related events triggered by IGF1R,
- Metabolism of proteins,
- Translation,
- Formation of a pool of free 40S subunits,
- 3' -UTR-mediated translational regulation,
- Cap-dependent Translation Initiation,
- Cleavage of Growing Transcript in the Termination Region,
- Transcription,
- Formation of the Early Elongation Complex,
- Formation of the ternary complex, and subsequently, the 43S complex,
- RNA Polymerase II Promoter Escape,
- Post-Elongation Processing of the Transcript,
- Nonsense Mediated Decay Independent of the Exon Junction Complex,
- Transport of Mature Transcript to Cytoplasm,
- Transport of Mature mRNA derived from an Intron-Containing Transcript,
- Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S,
- Formation of RNA Pol II elongation complex,
- RNA Polymerase II Transcription Initiation And Promoter Clearance,
- Nonsense Mediated Decay Enhanced by the Exon Junction Complex,
- Eukaryotic Translation Initiation,
- PKB-mediated events,
- Metabolism of mRNA,
- Eukaryotic Translation Elongation,
- Processing of Intronless Pre-mRNAs,
- mTOR signalling,
- Regulation of AMPK activity via LKB1,
- L13a-mediated translational silencing of Ceruloplasmin expression,
- mRNA Processing,
- Translation initiation complex formation,
- mTORC1-mediated signalling,
- Ribosomal scanning and start codon recognition,
- Transport of the SLBP Dependant Mature mRNA,
- Transport of Mature mRNAs Derived from Intronless Transcripts,
- Processing of Capped Intronless Pre-mRNA,
- Insulin signaling pathway
2 Cross References
Identifier |
Source . Name |
Subject . Primary Identifier |
---|---|---|
31700 | NCBI Entrez Gene identifiers | FBgn0261592 |
58174 | BioGRID | FBgn0261592 |
10 Data Sets
Name | URL |
---|---|
FlyBase data set for Drosophila melanogaster | |
Swiss-Prot data set | http://ca.expasy.org/sprot |
Drosophila 12 Genomes Consortium homology | |
GenomeRNAi data set | |
TreeFam data set | |
Panther data set | |
IntAct interactions data set | |
BioGRID interaction data set | http://www.thebiogrid.org/downloads.php |
GO Annotation from FlyBase | |
FlyBase fasta data set for Drosophila melanogaster |
24 RNAi Results
Screen | Gene | Phenotype | Score | Conditions | PubMed ID |
---|---|---|---|---|---|
Lipid storage | RpS6 | Increased lipid droplet area | 4.447277326 | 19067489 | |
Lipid storage | RpS6 | Increased lipid droplet area | 0.726340546 | 19067489 | |
Lipid storage | RpS6 | Increased lipid droplet area | 1.225438887 | 19067489 | |
Lipid storage | RpS6 | Increased lipid droplet area | 2.651270505 | 19067489 | |
Drosophila C virus infection | RpS6 | Drosophila C virus replication down | np | 17040126 | |
Cytokinesis regulation | RpS6 | Binucleate cells with decreased viability | medium | 15547975 | |
Intracellular Listeria monocytogenes infection | RpS6 | Increased GFP protein expression | moderate | 16020693 | |
Drosophila C virus infection | RpS6 | Drosophila C virus infection reduced | np | 15713840 | |
Hedgehog signaling | RpS6 | Decreased Hedgehog reporter activity | -2.87 | 16311596 | |
Constitutive protein secretion and Golgi organization (1) | RpS6 | Decreased horseradish peroxidase protein expression | sp | 16452979 | |
Cell size and cell-cycle regulation (1) | RpS6 | Increased G1 DNA content, decreased G2 DNA content, decreased viability, decreased cytokinesis | sp | 16496002 | |
Cell size and cell-cycle regulation (2) | RpS6 | none | 1.048 | 16496002 | |
Cell size and cell-cycle regulation (3) | RpS6 | none | 446 | 16496002 | |
Candida albicans phagocytosis (1) | RpS6 | none | np | 16336044 | |
Lipid storage | RpS6 | More dispersed droplets | strong (but ribosomal) | 18408709 | |
Combinatorial effect with methyl methanesulphonate (2) | RpS6 | Synthetic lethal with methyl methanesulphonate | sp | 19543366 | |
Mutant human huntingtin aggregation | RpS6 | Decreased mutant human huntingtin aggregation | <= -2 | 19789644 | |
Hh pathway regulation | RpS6 | Downregulation of Hh pathway | -0.501144770530667 | 17903264 | |
RTK-Ras-ERK pathway regulation (1) | RpS6 | none | 0.72 | 0 minutes EGF stimulation | 22028469 |
RTK-Ras-ERK pathway regulation (1) | RpS6 | Decreased ERK phosphorylation after EGF stimulation | -3.62 | 10 minutes EGF stimulation | 22028469 |
RTK-Ras-ERK pathway regulation (2) | RpS6 | Increased ERK phosphorylation after sSpitz and EGF stimulation | 1.87 | 10 minutes sSpitz stimulation | 22028469 |
RTK-Ras-ERK pathway regulation (2) | RpS6 | Increased ERK phosphorylation after sSpitz and EGF stimulation | 4.11 | 30 minutes sSpitz stimulation | 22028469 |
Hippo pathway regulation | RpS6 | none | -1.87 | 23263283 | |
Glycosylation regulation (1) | RpS6 | Decreased Chp protein expression | np | 21203496 |