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Gene : AGO2 D. melanogaster

DB identifier  ? FBgn0087035 Secondary Identifier  ? CG7439
Name  ? Argonaute 2 Source  FlyBase
  • synonyms:
  • argonaute 2,
  • ago,
  • dAGO2,
  • FBan0007439,
  • CG7439,
  • FBgn0040803,
  • Ago2,
  • eIF2C2,
  • FBgn0087035,
  • AG02,
  • Argonaute-2,
  • FBgn0036508,
  • CG13452,
  • Dm Ago2,
  • AGO 2,
  • FBgn0046812,
  • FBgn0004891,
  • Argonaute,
  • Ago-2,
  • ARGONAUTE2,
  • DmAgo2

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39 Alleles

DB identifier Symbol Allele Class Organism
FBal0243378 AGO2[S1008]   Drosophila melanogaster
FBal0138597 AGO2[dsRNA.C]   Drosophila melanogaster
FBal0198516 AGO2[alphaTub67C.PM]   Drosophila melanogaster
FBal0198517 AGO2[Scer\UAS.cMa]   Drosophila melanogaster
FBal0162853 AGO2[EY04479]   Drosophila melanogaster
FBal0157520 AGO2[EP3417]   Drosophila melanogaster
FBal0230230 AGO2[T:Zzzz\FLAG,T:Ivir\HA1]   Drosophila melanogaster
FBal0249325 AGO2[321] amorphic allele - molecular evidence Drosophila melanogaster
FBal0249326 AGO2[454]   Drosophila melanogaster
FBal0249327 AGO2[GM07030.Scer\UAS.T:Ivir\HA1]   Drosophila melanogaster
FBal0162856 AGO2[+t10.1]   Drosophila melanogaster
FBal0162854 AGO2[51B]   Drosophila melanogaster
FBal0128323 AGO2[dsRNA.2500-3435]   Drosophila melanogaster
FBal0261840 AGO2[CPTI002343]   Drosophila melanogaster
FBal0162855 AGO2[414] loss of function allele, hypomorphic allele - molecular evidence Drosophila melanogaster
FBal0162852 AGO2[dsRNA.cOa]   Drosophila melanogaster
FBal0141962 AGO2[dsRNA.cCa]   Drosophila melanogaster
FBal0157518 AGO2[dsRNA.si.3293-3315]   Drosophila melanogaster
FBal0188332 AGO2[dsRNA.cJa]   Drosophila melanogaster
FBal0136153 AGO2[dsRNA.cRa]   Drosophila melanogaster
FBal0157519 AGO2[dsRNA.si.1695-1717]   Drosophila melanogaster
FBal0141961 AGO2[dsRNA.cIa]   Drosophila melanogaster
FBal0128324 AGO2[dsRNA.1-1000]   Drosophila melanogaster
FBal0262355 AGO2[CPTI000743]   Drosophila melanogaster
FBal0263113 AGO2[HMS00108]   Drosophila melanogaster
FBal0141964 AGO2[MtnA.T:Zzzz\His6]   Drosophila melanogaster
FBal0141963 AGO2[MtnA.T:Zzzz\TAP]   Drosophila melanogaster
FBal0128325 AGO2[T:Uuuu\T7]   Drosophila melanogaster
FBal0198597 AGO2[GD17090]   Drosophila melanogaster
FBal0194866 AGO2[dsRNA.cDa]   Drosophila melanogaster

204 Clones

Secondary Identifier DB identifier
EK160519 FBcl0041592
EK133518 FBcl0041782
EK182541 FBcl0041874
EK226059 FBcl0041990
EK052421 FBcl0042002
EK169512 FBcl0042018
EK233152 FBcl0042034
EK244527 FBcl0042062
EK056645 FBcl0042078
EK119905 FBcl0047644
EK053532 FBcl0048054
bs16a06 FBcl0049903
EK072930 FBcl0052602
EK072910 FBcl0052708
EK087634 FBcl0052724
EK161145 FBcl0052744
EK177757 FBcl0052752
EK124629 FBcl0052760
EC28095 FBcl0064975
EC39533 FBcl0064987
EP21952 FBcl0079257
EN16714 FBcl0093985
EN07051 FBcl0093995
GM07030 FBcl0140061
GM08058 FBcl0140063
HL03146 FBcl0150631
LD01139 FBcl0162014
LP15542 FBcl0190644
RE39801 FBcl0235175
RE57933 FBcl0235185

10 Exons

DB identifier Symbol
FBgn0087035:1 AGO2:1
FBgn0087035:3 AGO2:3
FBgn0087035:5 AGO2:5
FBgn0087035:6 AGO2:6
FBgn0087035:7 AGO2:7
FBgn0087035:8 AGO2:8
FBgn0087035:9 AGO2:9
FBgn0087035:10 AGO2:10
FBgn0087035:2 AGO2:2
FBgn0087035:4 AGO2:4

3 Transcripts

DB identifier Gene
FBtr0075559 AGO2
FBtr0075560 AGO2
FBtr0331933 AGO2

6 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0075559-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0075560-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0331933-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0075559-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0075560-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0331933-3-prime-utr Drosophila melanogaster

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Other

0 Pathways

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
39683 NCBI Entrez Gene identifiers FBgn0087035
65002 BioGRID FBgn0087035

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0087035 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 9010.0
FBgn0087035 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 3383.0
FBgn0087035 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 5409.0
FBgn0087035 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 4895.0
FBgn0087035 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 4383.0
FBgn0087035 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 28025.0
FBgn0087035 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 12587.0
FBgn0087035 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 17990.0
FBgn0087035 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 24019.0
FBgn0087035 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 14025.0
FBgn0087035 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 15011.0
FBgn0087035 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 21237.0
FBgn0087035 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 14182.0
FBgn0087035 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 30998.0
FBgn0087035 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 21327.0
FBgn0087035 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 15542.0
FBgn0087035 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 14234.0
FBgn0087035 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 17170.0
FBgn0087035 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 17800.0
FBgn0087035 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 13105.0
FBgn0087035 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 13004.0
FBgn0087035 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 9700.0
FBgn0087035 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 10038.0
FBgn0087035 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 9213.0
FBgn0087035 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 8260.0
FBgn0087035 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 9235.0
FBgn0087035 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 9981.0
FBgn0087035 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 11776.0
FBgn0087035 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 8460.0
FBgn0087035 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 9048.0

9 Introns

DB identifier
Organism . Name
intron_FBgn0087035:4_FBgn0087035:6 Drosophila melanogaster
intron_FBgn0087035:6_FBgn0087035:7 Drosophila melanogaster
intron_FBgn0087035:7_FBgn0087035:8 Drosophila melanogaster
intron_FBgn0087035:8_FBgn0087035:9 Drosophila melanogaster
intron_FBgn0087035:9_FBgn0087035:10 Drosophila melanogaster
intron_FBgn0087035:1_FBgn0087035:3 Drosophila melanogaster
intron_FBgn0087035:3_FBgn0087035:5 Drosophila melanogaster
intron_FBgn0087035:5_FBgn0087035:6 Drosophila melanogaster
intron_FBgn0087035:2_FBgn0087035:5 Drosophila melanogaster

31 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage AGO2 none 0.385233697   19067489
Lipid storage AGO2 none -0.127674677   19067489
Lipid storage AGO2 none -0.082016462   19067489
Lipid storage AGO2 none 0.69398691   19067489
Lipid storage AGO2 none 1.062668181   19067489
ERK signaling AGO2 ERK activation reduced weak   17086199
E. coli / S. aureus infection AGO2 Cell death np   11912489
Imd pathway regulation AGO2 Increased Dipt::lacZ protein expression after lipopolysaccharide stimulation 27   15221030
Hedgehog signaling AGO2 Decreased Hedgehog reporter activity -2.79   16311596
Constitutive protein secretion and Golgi organization (1) AGO2 Decreased horseradish peroxidase protein expression sp   16452979
Cell size and cell-cycle regulation (1) AGO2 Decreased G1 DNA content, increased cytokinesis sp   16496002
Cell size and cell-cycle regulation (2) AGO2 none 1.163   16496002
Cell size and cell-cycle regulation (3) AGO2 Decreased cell number 416   16496002
Cell size and cell-cycle regulation (4) AGO2 none below threshold   16496002
RNAi pathway AGO2 Decreased RNAi silencing np   16862146
RNAi pathway AGO2 Decreased RNAi effect 78   16882716
Mitochondrial biogenesis and function AGO2 Decreased mitochondrial citrate synthase activity 0.519   18042644
Heat nociception (1) AGO2 none -1.17   21074052
Regulated secretory pathway biogenesis (1) AGO2 none 9.4   21149569
Serratia marcescens infection (1) AGO2 none -0.36986301369863   19520911
Notch pathway regulation (4) AGO2 none 0   19363474
Hh pathway regulation AGO2 none 0.250872755636622   17903264
Hh pathway regulation AGO2 none 0.313902966729524   17903264
Notch pathway regulation (3) AGO2 none np   20493818
Adiposity regulation (1) AGO2 none -0.045   20074523
RTK-Ras-ERK pathway regulation (1) AGO2 Decreased ERK phosphorylation after EGF stimulation -4.67 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) AGO2 Decreased ERK phosphorylation after EGF stimulation -3.77 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) AGO2 none 0.18 10 minutes sSpitz stimulation 22028469
RTK-Ras-ERK pathway regulation (2) AGO2 none 0.75 30 minutes sSpitz stimulation 22028469
Hippo pathway regulation AGO2 none 2.25   23263283

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