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Gene : Prosalpha2 D. melanogaster

DB identifier  ? FBgn0086134 Secondary Identifier  ? CG5266
Name  ? Proteasome alpha2 subunit Source  FlyBase
  • synonyms:
  • Proteosome,
  • FBan0005266,
  • Alpha-2,
  • Proteasome 25kD subunit,
  • FBgn0086134,
  • FBgn0010405,
  • Su(DTS)-1,
  • CG5266,
  • PROS-Dm25g,
  • Su(DTS),
  • dalpha2,
  • alpha2,
  • PRC3,
  • FBgn0024727,
  • Pros25,
  • Prosalpha2,
  • PROS Dm25,
  • 20S proteasome,
  • 153303_at,
  • alpha-subunit of 20S proteasome,
  • Proteasome subunit alpha-type 2,
  • alpha2_dm,
  • PSA2_DROME

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12 Alleles

DB identifier Symbol Allele Class Organism
FBal0287241 Prosalpha2[Scer\UAS.ORF]   Drosophila melanogaster
FBal0287242 Prosalpha2[Scer\UAS.ORF.T:Ivir\HA1]   Drosophila melanogaster
FBal0208133 Prosalpha2[GD15087]   Drosophila melanogaster
FBal0193261 Prosalpha2[+t2]   Drosophila melanogaster
FBal0193262 Prosalpha2[Scer\UAS.cNa]   Drosophila melanogaster
FBal0266403 Prosalpha2[GL01088]   Drosophila melanogaster
FBal0156046 Prosalpha2[dsRNA.cGa]   Drosophila melanogaster
FBal0193263 Prosalpha2[SuDTS.Scer\UAS]   Drosophila melanogaster
FBal0246900 Prosalpha2[G8948]   Drosophila melanogaster
FBal0236042 Prosalpha2[KK109089]   Drosophila melanogaster
FBal0130820 Prosalpha2[EP931]   Drosophila melanogaster
FBal0095585 Prosalpha2[SuDTS]   Drosophila melanogaster

113 Clones

Secondary Identifier DB identifier
EK295014 FBcl0026056
EK120242 FBcl0026082
EK295223 FBcl0026084
EK186837 FBcl0026086
EK244103 FBcl0026092
EK186852 FBcl0026098
EK267740 FBcl0026108
EK057805 FBcl0026126
bs63h11 FBcl0058741
bs48e09 FBcl0058743
EC34066 FBcl0073589
EC38453 FBcl0073593
EC28882 FBcl0073597
EC31253 FBcl0073599
GH21388 FBcl0131555
GH18725 FBcl0131559
GM04302 FBcl0143831
GM13604 FBcl0148542
LP20744 FBcl0189896
LP01456 FBcl0189900
RE22680 FBcl0232522
RE13374 FBcl0232537
RE59435 FBcl0232613
RH25789 FBcl0270033
RH55675 FBcl0270098
RH29430 FBcl0270125
RH28677 FBcl0270128
RH49133 FBcl0270141
RH28226 FBcl0270152
RH24704 FBcl0270194

5 Exons

DB identifier Symbol
FBgn0086134:1 Pros25:1
FBgn0086134:2 Pros25:2
FBgn0086134:3 Pros25:3
FBgn0086134:4 Pros25:4
FBgn0086134:5 Pros25:5

1 Transcripts

DB identifier Gene
FBtr0082590 Prosalpha2

2 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0082590-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0082590-3-prime-utr Drosophila melanogaster

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74 Pathways

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
41531 NCBI Entrez Gene identifiers FBgn0086134
66629 BioGRID FBgn0086134

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0086134 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 6779.0
FBgn0086134 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 6545.0
FBgn0086134 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 4632.0
FBgn0086134 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 8192.0
FBgn0086134 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 7176.0
FBgn0086134 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 5302.0
FBgn0086134 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 6388.0
FBgn0086134 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 7144.0
FBgn0086134 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 4363.0
FBgn0086134 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 7284.0
FBgn0086134 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 6369.0
FBgn0086134 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 6150.0
FBgn0086134 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 7122.0
FBgn0086134 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 8055.0
FBgn0086134 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 9279.0
FBgn0086134 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 7883.0
FBgn0086134 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 6036.0
FBgn0086134 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 4462.0
FBgn0086134 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 5856.0
FBgn0086134 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 4858.0
FBgn0086134 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 6941.0
FBgn0086134 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 5749.0
FBgn0086134 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 5025.0
FBgn0086134 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 5031.0
FBgn0086134 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 3770.0
FBgn0086134 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 11691.0
FBgn0086134 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 8462.0
FBgn0086134 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 4155.0
FBgn0086134 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 3225.0
FBgn0086134 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 3245.0

4 Introns

DB identifier
Organism . Name
intron_FBgn0086134:1_FBgn0086134:2 Drosophila melanogaster
intron_FBgn0086134:2_FBgn0086134:3 Drosophila melanogaster
intron_FBgn0086134:3_FBgn0086134:4 Drosophila melanogaster
intron_FBgn0086134:4_FBgn0086134:5 Drosophila melanogaster

20 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage Prosalpha2 none 1.085881396   19067489
Lipid storage Prosalpha2 none -0.672790551   19067489
Multipolar division Prosalpha2 Centrosome clustering defects medium   18662975
ERK signaling Prosalpha2 ERK activation reduced weak   17086199
Intracellular Listeria monocytogenes infection Prosalpha2 Decreased GFP protein expression strong   16020693
Constitutive protein secretion and Golgi organization (1) Prosalpha2 Decreased horseradish peroxidase protein expression sp   16452979
Cell size and cell-cycle regulation (1) Prosalpha2 none sp   16496002
Muscle morphogenesis and function (1) Prosalpha2 Lethal np   20220848
Muscle morphogenesis and function (2) Prosalpha2 Wing posture / locomotion / ability to fly defect or lethal / semi-lethal np   20220848
Muscle morphogenesis and function (3) Prosalpha2 Spotty (discontinuous) Z-line np   20220848
Heat nociception (1) Prosalpha2 none -1.17   21074052
Heart development and function (1) Prosalpha2 Adult lethal 0   20371351
Notch pathway regulation (4) Prosalpha2 Completely lethal (before pupal) sp   19363474
PGN-induced dJNK phosphorylation Prosalpha2 Increased P-JNK protein expression with PGN 2.49 15 min PGN induction 19893628
RTK-Ras-ERK pathway regulation (1) Prosalpha2 Decreased ERK phosphorylation after EGF stimulation -1.69 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) Prosalpha2 Decreased ERK phosphorylation after EGF stimulation -3.53 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Prosalpha2 Increased ERK phosphorylation after sSpitz and EGF stimulation 1.63 10 minutes sSpitz stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Prosalpha2 Increased ERK phosphorylation after sSpitz and EGF stimulation 1.96 30 minutes sSpitz stimulation 22028469
Hippo pathway regulation Prosalpha2 none -0.4   23263283
Glycosylation regulation (4) Prosalpha2 Decreased (GlcNAc)n Chp glycosylation, decreased mannose Chp glycosylation sp   21203496

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