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Gene : MED4 D. melanogaster
DB identifier  ? FBgn0035754 Secondary Identifier  ? CG8609
Name  ? Mediator complex subunit 4 Source  FlyBase
  • synonyms:
  • CG8609,
  • dTRAP36,
  • FBan0008609,
  • Med4/TRAP36,
  • Trap36,
  • Med4,
  • p34,
  • Mediator,
  • dp34,
  • FBgn0035754
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Lists
This Gene is in 2 lists:
Fly classI (1496)
Fly classIa (363)

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5 Alleles

DB identifier Symbol Allele Class Organism
FBal0257835 MED4[HMS01176]   Drosophila melanogaster
FBal0182840 MED4[a.cKa]   Drosophila melanogaster
FBal0182839 MED4[cKa]   Drosophila melanogaster
FBal0207562 MED4[GD5848]   Drosophila melanogaster
FBal0235721 MED4[KK108661]   Drosophila melanogaster

6 Clones

Secondary Identifier DB identifier
AT13844 FBcl0023663
LD03550 FBcl0154006
LD46084 FBcl0167137
RE68193 FBcl0204244
UT01420 FBcl0292725
Dmel_dig_011268_0675_2513 FBcl0381150

2 Exons

DB identifier Symbol
FBgn0035754:2 MED4:2
FBgn0035754:1 MED4:1

1 Transcripts

DB identifier Gene
FBtr0076889 MED4

2 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0076889-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0076889-3-prime-utr Drosophila melanogaster

Interactions

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Other

2 Pathways

2 Cross References

Identifier
Source . Name
Subject . Primary Identifier
38799 NCBI Entrez Gene identifiers FBgn0035754
64242 BioGRID FBgn0035754

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier
Submission . Title
Cell Line . Name
Developmental Stage . Name 		Score
FBgn0035754 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 341.0
FBgn0035754 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 334.0
FBgn0035754 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 144.0
FBgn0035754 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 419.0
FBgn0035754 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 282.0
FBgn0035754 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 377.0
FBgn0035754 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 241.0
FBgn0035754 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 464.0
FBgn0035754 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 84.0
FBgn0035754 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 523.0
FBgn0035754 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 500.0
FBgn0035754 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 130.0
FBgn0035754 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 258.0
FBgn0035754 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 454.0
FBgn0035754 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 164.0
FBgn0035754 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 409.0
FBgn0035754 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 311.0
FBgn0035754 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 458.0
FBgn0035754 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 434.0
FBgn0035754 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 304.0
FBgn0035754 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 619.0
FBgn0035754 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 319.0
FBgn0035754 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 300.0
FBgn0035754 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 416.0
FBgn0035754 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 153.0
FBgn0035754 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 757.0
FBgn0035754 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 953.0
FBgn0035754 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 372.0
FBgn0035754 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 356.0
FBgn0035754 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 415.0

1 Introns

DB identifier
Organism . Name
intron_FBgn0035754:2_FBgn0035754:1 Drosophila melanogaster

24 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage MED4 none 0.456761829   19067489
Lipid storage MED4 none 0.295262641   19067489
ERK signaling MED4 ERK activation increased strong   17086199
Constitutive protein secretion and Golgi organization (1) MED4 Decreased horseradish peroxidase protein expression sp   16452979
Cell size and cell-cycle regulation (1) MED4 none sp   16496002
Dendrite pattern formation MED4 Increased 1st branch extension, decreased lateral branching np   16547170
Microtubule assembly and organization MED4 none np   18463163
Mutant human huntingtin aggregation MED4 Decreased mutant human huntingtin aggregation <= -2   19789644
Muscle morphogenesis and function (1) MED4 none np   20220848
Heat nociception (1) MED4 none 1.04   21074052
Heart development and function (1) MED4 none 1   20371351
Serratia marcescens infection (1) MED4 none -1.41304347826086   19520911
Notch pathway regulation (4) MED4 Notum malformation death 8   19363474
G2-M DNA damage checkpoint regulation (2) MED4 Increased histone H3 phosphorylation with doxorubicin 32.7 with doxorubicin 21205937
G2-M DNA damage checkpoint regulation (2) MED4 none 23.33 with etoposide 21205937
G2-M DNA damage checkpoint regulation (2) MED4 Increased histone H3 phosphorylation after X-ray exposure 45.31 X-ray exposure 21205937
G2-M DNA damage checkpoint regulation (2) MED4 Increased histone H3 phosphorylation with bleocin 17.31 with bleocin 21205937
Adiposity regulation (1) MED4 none -0.141   20074523
RTK-Ras-ERK pathway regulation (1) MED4 none 0.35 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) MED4 none -0.77 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) MED4 Increased ERK phosphorylation after sSpitz and EGF stimulation 1.88 30 minutes sSpitz stimulation 22028469
RTK-Ras-ERK pathway regulation (2) MED4 Increased ERK phosphorylation after sSpitz and EGF stimulation 2.14 10 minutes sSpitz stimulation 22028469
Hippo pathway regulation MED4 none 0.1   23263283
Srp/Lz-induced transcriptional activation MED4 Decreased Srp/Lz-induced transcription -10.49   20368357

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