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Gene : CSN6 D. melanogaster

DB identifier  ? FBgn0028837 Secondary Identifier  ? CG6932
Name  ? COP9 complex homolog subunit 6 Source  FlyBase
  • synonyms:
  • Drosophila COP9 signalosome homolog 6,
  • FBgn0028837,
  • CG6932,
  • Csn6,
  • CH6,
  • FBan0006932,
  • Dch6

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7 Alleles

DB identifier Symbol Allele Class Organism
FBal0184454 CSN6[f03517]   Drosophila melanogaster
FBal0262957 CSN6[GL00492]   Drosophila melanogaster
FBal0287048 CSN6[Scer\UAS.ORF]   Drosophila melanogaster
FBal0287049 CSN6[Scer\UAS.ORF.T:Ivir\HA1]   Drosophila melanogaster
FBal0206467 CSN6[GD12078]   Drosophila melanogaster
FBal0279389 CSN6[HMS02392]   Drosophila melanogaster
FBal0230708 CSN6[KK100377]   Drosophila melanogaster

21 Clones

Secondary Identifier DB identifier
bs50g12 FBcl0054655
EK298822 FBcl0072888
EK157021 FBcl0074350
EP02249 FBcl0085757
EN06803 FBcl0099525
GM22205 FBcl0147360
LD46454 FBcl0171529
LD39711 FBcl0171543
LP14162 FBcl0185976
RE73039 FBcl0217206
RE71054 FBcl0217364
RH42524 FBcl0257039
RH33430 FBcl0257983
SD24335 FBcl0288568
SD16384 FBcl0288592
32034 FBcl0406092
38211 FBcl0406071
214505.3 FBcl0406077
47433 FBcl0406100
43552 FBcl0406118
42194 FBcl0406125

2 Exons

DB identifier Symbol
FBgn0028837:1 CSN6:1
FBgn0028837:2 CSN6:2

1 Transcripts

DB identifier Gene
FBtr0084265 CSN6

2 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0084265-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0084265-3-prime-utr Drosophila melanogaster

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0 Pathways

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
42661 NCBI Entrez Gene identifiers FBgn0028837
67615 BioGRID FBgn0028837

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0028837 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 1122.0
FBgn0028837 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 1148.0
FBgn0028837 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 436.0
FBgn0028837 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 1289.0
FBgn0028837 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 1210.0
FBgn0028837 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 459.0
FBgn0028837 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 668.0
FBgn0028837 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 747.0
FBgn0028837 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 975.0
FBgn0028837 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 969.0
FBgn0028837 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 767.0
FBgn0028837 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 750.0
FBgn0028837 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 649.0
FBgn0028837 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 1113.0
FBgn0028837 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 1089.0
FBgn0028837 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 845.0
FBgn0028837 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 957.0
FBgn0028837 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 441.0
FBgn0028837 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 1194.0
FBgn0028837 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 1118.0
FBgn0028837 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 801.0
FBgn0028837 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 762.0
FBgn0028837 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 684.0
FBgn0028837 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 626.0
FBgn0028837 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 422.0
FBgn0028837 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 1656.0
FBgn0028837 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 1324.0
FBgn0028837 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 802.0
FBgn0028837 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 717.0
FBgn0028837 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 804.0

1 Introns

DB identifier
Organism . Name
intron_FBgn0028837:1_FBgn0028837:2 Drosophila melanogaster

31 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage CSN6 none 0.401334094   19067489
Lipid storage CSN6 none -0.093513483   19067489
Cell size and cell-cycle regulation (1) CSN6 Increased G1 DNA content, decreased G2 DNA content sp   16496002
Cell size and cell-cycle regulation (1) CSN6 Increased G1 DNA content, decreased G2 DNA content, increased G1 cell size sp   16496002
Cell size and cell-cycle regulation (2) CSN6 none 1.066   16496002
Cell size and cell-cycle regulation (2) CSN6 none 1.251   16496002
Cell size and cell-cycle regulation (3) CSN6 Decreased cell number 386   16496002
Cell size and cell-cycle regulation (3) CSN6 none 438   16496002
Cell size and cell-cycle regulation (4) CSN6 none below threshold   16496002
Muscle morphogenesis and function (1) CSN6 Day 7 lethal np   20220848
Muscle morphogenesis and function (1) CSN6 none np   20220848
Heat nociception (1) CSN6 none -0.26   21074052
Heart development and function (1) CSN6 none 1   20371351
Serratia marcescens infection (1) CSN6 none -0.0864197530864197   19520911
Serratia marcescens infection (1) CSN6 none 0.741935483870967   19520911
Notch pathway regulation (4) CSN6 Gain of bristles, hair cell duplication, notum malformation death, lateral inhibition sp   19363474
Notch pathway regulation (4) CSN6 Gain of bristles, loss of bristles, hair cell duplication, bristle morphology defects, notum malformation death, lateral inhibition sp   19363474
PGN-induced dJNK phosphorylation CSN6 Increased P-JNK protein expression with PGN 2.16 60 min PGN induction 19893628
G2-M DNA damage checkpoint regulation (2) CSN6 Increased histone H3 phosphorylation with doxorubicin 24.87 with doxorubicin 21205937
G2-M DNA damage checkpoint regulation (2) CSN6 Increased histone H3 phosphorylation with etoposide 37.18 with etoposide 21205937
G2-M DNA damage checkpoint regulation (2) CSN6 Increased histone H3 phosphorylation after X-ray exposure 53.82 X-ray exposure 21205937
G2-M DNA damage checkpoint regulation (2) CSN6 Increased histone H3 phosphorylation with bleocin 24.44 with bleocin 21205937
Self-renewal and differentiation in neural stem cells CSN6 GFP aggregates number, lethal sp   21549331
Adiposity regulation (1) CSN6 none -0.219   20074523
Adiposity regulation (1) CSN6 none -0.134   20074523
S2 cell spreading CSN6 none np   21041442
RTK-Ras-ERK pathway regulation (1) CSN6 none 0.16 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) CSN6 none 1.17 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) CSN6 Increased ERK phosphorylation after sSpitz and EGF stimulation 2.86 30 minutes sSpitz stimulation 22028469
RTK-Ras-ERK pathway regulation (2) CSN6 Increased ERK phosphorylation after sSpitz and EGF stimulation 3.26 10 minutes sSpitz stimulation 22028469

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