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Gene : eIF5B D. melanogaster

DB identifier  ? FBgn0026259 Secondary Identifier  ? CG10840
Name  ? eIF5B Source  FlyBase
  • synonyms:
  • FBgn0026259,
  • eukaryotic initiation factor 5B,
  • cytoplasmic Initiation Factor 2,
  • CG10840,
  • FBgn0035447,
  • FBgn0035446,
  • IF2,
  • CG14970,
  • A1,
  • anon-WO0118547.362,
  • cIF2,
  • dIF2,
  • FBgn0062068,
  • yIF2,
  • FBan0010840,
  • Eif5b

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14 Alleles

DB identifier Symbol Allele Class Organism
FBal0282970 eIF5B[MI07293]   Drosophila melanogaster
FBal0159279 eIF5B[EY01401]   Drosophila melanogaster
FBal0155362 eIF5B[09143]   Drosophila melanogaster
FBal0259384 eIF5B[KK105498]   Drosophila melanogaster
FBal0121837 eIF5B[Delta2]   Drosophila melanogaster
FBal0121838 eIF5B[Delta1]   Drosophila melanogaster
FBal0147241 eIF5B[KG09489]   Drosophila melanogaster
FBal0121836 eIF5B[unspecified]   Drosophila melanogaster
FBal0261539 eIF5B[CPTI003501]   Drosophila melanogaster
FBal0270625 eIF5B[NIG.10840R]   Drosophila melanogaster
FBal0209484 eIF5B[GD7105]   Drosophila melanogaster
FBal0265256 eIF5B[MI02930]   Drosophila melanogaster
FBal0242802 eIF5B[MI00125]   Drosophila melanogaster
FBal0222513 eIF5B[c02932]   Drosophila melanogaster

84 Clones

Secondary Identifier DB identifier
523180 FBcl0422800
CK01.87B.B2 FBcl0418678
CK01.17B.D2 FBcl0418679
CK01.23B.F3 FBcl0418686
FI21107 FBcl0743427
FI21119 FBcl0743457
bs46d04 FBcl0047849
bs61c09 FBcl0047851
EP21428 FBcl0075469
EP17319 FBcl0075471
EK174146 FBcl0087696
EK235233 FBcl0087726
EK069037 FBcl0087760
EK061153 FBcl0087768
EN01714 FBcl0091735
EN05359 FBcl0091737
EN16902 FBcl0091741
EN16824 FBcl0091743
EN03551 FBcl0091745
EN17839 FBcl0091747
EN03122 FBcl0091751
GM10390 FBcl0138249
GM29011 FBcl0144314
GM21079 FBcl0144315
GM20554 FBcl0144317
GM16290 FBcl0144318
GM31807 FBcl0144319
LD42524 FBcl0165441
LP06476 FBcl0181454
LP03795 FBcl0181485

12 Exons

DB identifier Symbol
FBgn0026259:1 eIF5B:1
FBgn0026259:10 eIF5B:10
FBgn0026259:9 eIF5B:9
FBgn0026259:8 eIF5B:8
FBgn0026259:7 eIF5B:7
FBgn0026259:6 eIF5B:6
FBgn0026259:5 eIF5B:5
FBgn0026259:4 eIF5B:4
FBgn0026259:3 eIF5B:3
FBgn0026259:2 eIF5B:2
FBgn0026259:12 eIF5B:12
FBgn0026259:11 eIF5B:11

5 Transcripts

DB identifier Gene
FBtr0309837 eIF5B
FBtr0309838 eIF5B
FBtr0309836 eIF5B
FBtr0073144 eIF5B
FBtr0309839 eIF5B

10 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0073144-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0309836-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0309837-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0309838-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0309839-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0073144-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0309836-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0309837-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0309838-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0309839-3-prime-utr Drosophila melanogaster

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38 Pathways

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
44261 NCBI Entrez Gene identifiers FBgn0026259
68928 BioGRID FBgn0026259

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
TrEMBL data set http://www.ebi.ac.uk/trembl/
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0026259 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 3621.0
FBgn0026259 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 5616.0
FBgn0026259 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 5189.0
FBgn0026259 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 2402.0
FBgn0026259 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 1666.0
FBgn0026259 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 4089.0
FBgn0026259 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 1635.0
FBgn0026259 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 4396.0
FBgn0026259 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 1061.0
FBgn0026259 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 2591.0
FBgn0026259 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 2467.0
FBgn0026259 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 2865.0
FBgn0026259 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 1785.0
FBgn0026259 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 2452.0
FBgn0026259 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 1866.0
FBgn0026259 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 2062.0
FBgn0026259 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 2497.0
FBgn0026259 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 2297.0
FBgn0026259 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 1573.0
FBgn0026259 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 2170.0
FBgn0026259 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 2115.0
FBgn0026259 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 11007.0
FBgn0026259 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 2037.0
FBgn0026259 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 6966.0
FBgn0026259 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 2824.0
FBgn0026259 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 2700.0
FBgn0026259 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 733.0
FBgn0026259 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 1077.0
FBgn0026259 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 1237.0
FBgn0026259 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 1216.0

14 Introns

DB identifier
Organism . Name
intron_FBgn0026259:10_FBgn0026259:9 Drosophila melanogaster
intron_FBgn0026259:9_FBgn0026259:8 Drosophila melanogaster
intron_FBgn0026259:8_FBgn0026259:7 Drosophila melanogaster
intron_FBgn0026259:7_FBgn0026259:6 Drosophila melanogaster
intron_FBgn0026259:6_FBgn0026259:5 Drosophila melanogaster
intron_FBgn0026259:5_FBgn0026259:3 Drosophila melanogaster
intron_FBgn0026259:3_FBgn0026259:1 Drosophila melanogaster
intron_FBgn0026259:12_FBgn0026259:11 Drosophila melanogaster
intron_FBgn0026259:11_FBgn0026259:9 Drosophila melanogaster
intron_FBgn0026259:5_FBgn0026259:4 Drosophila melanogaster
intron_FBgn0026259:4_FBgn0026259:3 Drosophila melanogaster
intron_FBgn0026259:3_FBgn0026259:2 Drosophila melanogaster
intron_FBgn0026259:4_FBgn0026259:1 Drosophila melanogaster
intron_FBgn0026259:12_FBgn0026259:10 Drosophila melanogaster

33 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage eIF5B none -0.042413293   19067489
Lipid storage eIF5B none 2.383803938   19067489
Lipid storage eIF5B none 0.939366747   19067489
Lipid storage eIF5B none 1.737588687   19067489
ERK signaling eIF5B ERK activation reduced weak   17086199
Imd pathway regulation eIF5B Decreased Dipt::lacZ protein expression after lipopolysaccharide stimulation 2   15221030
Constitutive protein secretion and Golgi organization (1) eIF5B Decreased horseradish peroxidase protein expression sp   16452979
Constitutive protein secretion and Golgi organization (1) eIF5B Decreased horseradish peroxidase protein expression sp   16452979
Cell size and cell-cycle regulation (1) eIF5B none sp   16496002
Combinatorial effect with methyl methanesulphonate (1) eIF5B none sp   19543366
Combinatorial effect with methyl methanesulphonate (2) eIF5B Synthetic lethal with methyl methanesulphonate sp   19543366
Muscle morphogenesis and function (1) eIF5B Lethal np   20220848
Muscle morphogenesis and function (1) eIF5B Lethal np   20220848
Muscle morphogenesis and function (3) eIF5B none np   20220848
Heat nociception (1) eIF5B Developmentally lethal 1.41   21074052
Heart development and function (1) eIF5B Pupal lethal 0.25   20371351
Serratia marcescens infection (1) eIF5B none 0.183333333333333   19520911
Serratia marcescens infection (1) eIF5B none 0.554347826086956   19520911
Notch pathway regulation (4) eIF5B Completely lethal (before pupal) sp   19363474
Notch pathway regulation (4) eIF5B Completely lethal (pupal) sp   19363474
Adiposity regulation (1) eIF5B Decreased triglyceride expression -0.681   20074523
Adiposity regulation (1) eIF5B Decreased triglyceride expression -0.492   20074523
Adiposity regulation (2) eIF5B Increased triglyceride expression 0.684   20074523
Adiposity regulation (3) eIF5B Lethal or developmental delay d/l   20074523
Adiposity regulation (4) eIF5B Lethal or developmental delay d/l   20074523
Adiposity regulation (5) eIF5B Lethal or developmental delay d/l   20074523
RTK-Ras-ERK pathway regulation (1) eIF5B Increased ERK phosphorylation after EGF stimulation 3.93 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) eIF5B Decreased ERK phosphorylation after EGF stimulation -1.87 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) eIF5B none 1.34 30 minutes sSpitz stimulation 22028469
RTK-Ras-ERK pathway regulation (2) eIF5B none -1.16 10 minutes sSpitz stimulation 22028469

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