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Gene : MED6 D. melanogaster

DB identifier  ? FBgn0024330 Secondary Identifier  ? CG9473
Name  ? Mediator complex subunit 6 Source  FlyBase
  • synonyms:
  • dTRAP32,
  • Mediator,
  • dMED6,
  • FBgn0027700,
  • FBan0009473,
  • CG9473,
  • BcDNA:LD15729,
  • FBgn0063159,
  • Trap32,
  • Med6,
  • FBgn0037748,
  • FBgn0024330,
  • anon-EST:Posey279,
  • p35

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11 Alleles

DB identifier Symbol Allele Class Organism
FBal0160200 MED6[EY05087]   Drosophila melanogaster
FBal0257745 MED6[HMS01081]   Drosophila melanogaster
FBal0182838 MED6[a.cKa]   Drosophila melanogaster
FBal0182837 MED6[cKa]   Drosophila melanogaster
FBal0150765 MED6[T:Ivir\HA1]   Drosophila melanogaster
FBal0207563 MED6[GD4732]   Drosophila melanogaster
FBal0242671 MED6[26] amorphic allele - genetic evidence Drosophila melanogaster
FBal0242672 MED6[64] amorphic allele - genetic evidence Drosophila melanogaster
FBal0242673 MED6[+t10.4]   Drosophila melanogaster
FBal0242674 MED6[unspecified]   Drosophila melanogaster
FBal0231574 MED6[KK101944]   Drosophila melanogaster

98 Clones

Secondary Identifier DB identifier
AF171864 FBcl0000249
EK220939 FBcl0013154
EK048528 FBcl0013196
EP19345 FBcl0078751
EN03653 FBcl0093993
GM17606 FBcl0145301
GM28719 FBcl0145302
LD15729 FBcl0151100
LD17085 FBcl0151106
LD13271 FBcl0151138
LD06223 FBcl0151142
LD09827 FBcl0151178
LD36458 FBcl0163210
LD37008 FBcl0163324
LD33712 FBcl0163327
LP02921 FBcl0179335
LP06029 FBcl0179339
LP13268 FBcl0179879
RE19085 FBcl0192347
RE32580 FBcl0192527
RE42640 FBcl0192582
RE38674 FBcl0192753
SD22018 FBcl0280701
523227 FBcl0439180
CK01.61C.G7 FBcl0439066
RP004207358 FBcl0526328
RP004327521 FBcl0526329
RP004237920 FBcl0526330
RP004198417 FBcl0526331
RP004451902 FBcl0526332

9 Exons

DB identifier Symbol
FBgn0024330:9 MED6:9
FBgn0024330:5 MED6:5
FBgn0024330:3 MED6:3
FBgn0024330:2 MED6:2
FBgn0024330:1 MED6:1
FBgn0024330:8 MED6:8
FBgn0024330:7 MED6:7
FBgn0024330:6 MED6:6
FBgn0024330:4 MED6:4

5 Transcripts

DB identifier Gene
FBtr0082161 MED6
FBtr0082162 MED6
FBtr0301872 MED6
FBtr0301873 MED6
FBtr0339719 MED6

10 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0082161-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0082162-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0301872-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0301873-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0339719-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0082161-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0082162-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0301872-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0301873-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0339719-3-prime-utr Drosophila melanogaster

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Other

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
44728 NCBI Entrez Gene identifiers FBgn0024330
69231 BioGRID FBgn0024330

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0024330 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 808.0
FBgn0024330 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 600.0
FBgn0024330 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 376.0
FBgn0024330 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 696.0
FBgn0024330 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 941.0
FBgn0024330 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 562.0
FBgn0024330 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 859.0
FBgn0024330 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 1054.0
FBgn0024330 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 465.0
FBgn0024330 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 1013.0
FBgn0024330 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 761.0
FBgn0024330 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 851.0
FBgn0024330 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 742.0
FBgn0024330 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 794.0
FBgn0024330 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 557.0
FBgn0024330 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 832.0
FBgn0024330 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 601.0
FBgn0024330 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 742.0
FBgn0024330 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 798.0
FBgn0024330 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 605.0
FBgn0024330 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 1057.0
FBgn0024330 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 784.0
FBgn0024330 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 565.0
FBgn0024330 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 646.0
FBgn0024330 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 694.0
FBgn0024330 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 1154.0
FBgn0024330 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 580.0
FBgn0024330 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 483.0
FBgn0024330 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 653.0
FBgn0024330 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 576.0

8 Introns

DB identifier
Organism . Name
intron_FBgn0024330:9_FBgn0024330:5 Drosophila melanogaster
intron_FBgn0024330:5_FBgn0024330:3 Drosophila melanogaster
intron_FBgn0024330:3_FBgn0024330:2 Drosophila melanogaster
intron_FBgn0024330:2_FBgn0024330:1 Drosophila melanogaster
intron_FBgn0024330:7_FBgn0024330:5 Drosophila melanogaster
intron_FBgn0024330:6_FBgn0024330:5 Drosophila melanogaster
intron_FBgn0024330:4_FBgn0024330:3 Drosophila melanogaster
intron_FBgn0024330:8_FBgn0024330:5 Drosophila melanogaster

23 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage MED6 Increased lipid droplet area 3.047382431   19067489
Lipid storage MED6 Increased lipid droplet area 6.635097405   19067489
ERK signaling MED6 ERK activation increased weak   17086199
Constitutive protein secretion and Golgi organization (1) MED6 Decreased horseradish peroxidase protein expression sp   16452979
Cell size and cell-cycle regulation (1) MED6 none sp   16496002
Dendrite pattern formation MED6 none np   16547170
Muscle morphogenesis and function (1) MED6 Lethal np   20220848
Muscle morphogenesis and function (1) MED6 Lethal np   20220848
Heat nociception (1) MED6 none -0.01   21074052
Heart development and function (1) MED6 none 1   20371351
Serratia marcescens infection (1) MED6 Increased viability after Serratia marcescens infection 2.89393939393939   19520911
Serratia marcescens infection (2) MED6 Increased viability after Serratia marcescens infection sp   19520911
Serratia marcescens infection (4) MED6 Increased viability after Serratia marcescens infection sp   19520911
Notch pathway regulation (4) MED6 Gain of bristles, notum malformation death, lateral inhibition sp   19363474
Notch pathway regulation (4) MED6 Bristle morphology defects, notum malformation death sp   19363474
Notch pathway regulation (5) MED6 Wrinkled wings np   19363474
Adiposity regulation (1) MED6 none -0.242   20074523
RTK-Ras-ERK pathway regulation (1) MED6 none -0.31 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) MED6 none 0.13 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) MED6 none 0.35 30 minutes sSpitz stimulation 22028469
RTK-Ras-ERK pathway regulation (2) MED6 Increased ERK phosphorylation after sSpitz and EGF stimulation 1.55 10 minutes sSpitz stimulation 22028469
Hippo pathway regulation MED6 none -2.55   23263283
Srp/Lz-induced transcriptional activation MED6 Decreased Srp/Lz-induced transcription -5.72   20368357

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