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Gene : Cdk8 D. melanogaster

DB identifier  ? FBgn0015618 Secondary Identifier  ? CG10572
Name  ? Cyclin-dependent kinase 8 Source  FlyBase
  • synonyms:
  • FBan0010572,
  • FBgn0015618,
  • CDK8,
  • dTRAP56,
  • p58,
  • dCdk8,
  • DmCdk8,
  • CG10572

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13 Alleles

DB identifier Symbol Allele Class Organism
FBal0263548 Cdk8[Ubi-p63E.PL]   Drosophila melanogaster
FBal0283016 Cdk8[c01804]   Drosophila melanogaster
FBal0242962 Cdk8[H2480]   Drosophila melanogaster
FBal0242963 Cdk8[GMR.PB]   Drosophila melanogaster
FBal0282538 Cdk8[dsRNA.Scer\UAS]   Drosophila melanogaster
FBal0160706 Cdk8[A162]   Drosophila melanogaster
FBal0286520 Cdk8[Scer\UAS.ORF]   Drosophila melanogaster
FBal0286521 Cdk8[Scer\UAS.ORF.T:Ivir\HA1]   Drosophila melanogaster
FBal0270518 Cdk8[NIG.10572R]   Drosophila melanogaster
FBal0262702 Cdk8[GL00231]   Drosophila melanogaster
FBal0218350 Cdk8[K185] amorphic allele - molecular evidence, amorphic allele - genetic evidence Drosophila melanogaster
FBal0206545 Cdk8[GD7022]   Drosophila melanogaster
FBal0235129 Cdk8[KK107735]   Drosophila melanogaster

7 Clones

Secondary Identifier DB identifier
RE13344 FBcl0210991
RM06792 FBcl0381820
RM07192 FBcl0381821
RM06692 FBcl0381822
RM06992 FBcl0381823
RM07292 FBcl0381824
FI03233 FBcl0718770

2 Exons

DB identifier Symbol
FBgn0015618:2 Cdk8:2
FBgn0015618:1 Cdk8:1

1 Transcripts

DB identifier Gene
FBtr0076369 Cdk8

2 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0076369-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0076369-3-prime-utr Drosophila melanogaster

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2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
39157 NCBI Entrez Gene identifiers FBgn0015618
64544 BioGRID FBgn0015618

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0015618 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 164.0
FBgn0015618 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 171.0
FBgn0015618 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 155.0
FBgn0015618 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 177.0
FBgn0015618 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 258.0
FBgn0015618 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 178.0
FBgn0015618 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 188.0
FBgn0015618 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 246.0
FBgn0015618 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 211.0
FBgn0015618 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 281.0
FBgn0015618 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 330.0
FBgn0015618 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 161.0
FBgn0015618 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 184.0
FBgn0015618 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 235.0
FBgn0015618 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 370.0
FBgn0015618 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 352.0
FBgn0015618 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 184.0
FBgn0015618 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 171.0
FBgn0015618 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 214.0
FBgn0015618 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 117.0
FBgn0015618 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 343.0
FBgn0015618 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 199.0
FBgn0015618 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 244.0
FBgn0015618 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 284.0
FBgn0015618 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 128.0
FBgn0015618 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 775.0
FBgn0015618 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 454.0
FBgn0015618 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 606.0
FBgn0015618 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 352.0
FBgn0015618 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 240.0

1 Introns

DB identifier
Organism . Name
intron_FBgn0015618:2_FBgn0015618:1 Drosophila melanogaster

45 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage Cdk8 none 0.079622947   19067489
Lipid storage Cdk8 none -0.106746601   19067489
Cell morphology Cdk8 Morphology np   14527345
Cell cycle regulation (1) Cdk8 Increased S DNA content, equal G1 and G2/M DNA content sp   15616552
Cell cycle regulation (2) Cdk8 Increased S DNA content or increased number of aneuploid cells, decreased G2 DNA content np   15616552
Cell size and cell-cycle regulation (1) Cdk8 Increased G1 DNA content, decreased G2 DNA content sp   16496002
Cell size and cell-cycle regulation (1) Cdk8 none sp   16496002
Cell size and cell-cycle regulation (1) Cdk8 none sp   16496002
Cell size and cell-cycle regulation (2) Cdk8 none 0.95   16496002
Cell size and cell-cycle regulation (3) Cdk8 none 456   16496002
Dendrite pattern formation Cdk8 none np   16547170
Muscle morphogenesis and function (1) Cdk8 none np   20220848
Muscle morphogenesis and function (1) Cdk8 none np   20220848
Heat nociception (1) Cdk8 none -0.1   21074052
Heart development and function (1) Cdk8 none 1   20371351
Serratia marcescens infection (1) Cdk8 none 0.528571428571428   19520911
Notch pathway regulation (4) Cdk8 Notum malformation migration, overproliferation sp   19363474
Notch pathway regulation (4) Cdk8 Notum malformation migration, overproliferation sp   19363474
Notch pathway regulation (4) Cdk8 Loss of bristles, notum malformation migration, overproliferation sp   19363474
Notch induced transcription Cdk8 none -0.63955 N(delta)ecn Notch stimulation 20959007
Notch induced transcription Cdk8 none -0.7551 without Notch stimulation 20959007
Notch induced transcription Cdk8 Downregulation of Notch pathway after Notch stimulation -2.1741 N(delta)ecn Notch stimulation 20959007
G2-M DNA damage checkpoint regulation (2) Cdk8 Increased histone H3 phosphorylation with bleocin 59.14 with bleocin 21205937
G2-M DNA damage checkpoint regulation (2) Cdk8 Increased histone H3 phosphorylation with doxorubicin 58.87 with doxorubicin 21205937
G2-M DNA damage checkpoint regulation (2) Cdk8 Increased histone H3 phosphorylation with etoposide 43.77 with etoposide 21205937
G2-M DNA damage checkpoint regulation (2) Cdk8 Increased histone H3 phosphorylation after X-ray exposure 60.28 X-ray exposure 21205937
Pol II elongation Cdk8 Decreased Hsp70 mRNA expression 60 20 min heat shock 19279664
Pol II elongation Cdk8 Decreased Hsp70 mRNA expression 60 20 min heat shock 19279664
Adiposity regulation (1) Cdk8 none -1   20074523
Blood cell homeostasis regulation (1) Cdk8 none np   20540764

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