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Gene : Pabp2 D. melanogaster

DB identifier  ? FBgn0005648 Secondary Identifier  ? CG2163
Name  ? Pabp2 Source  FlyBase
  • synonyms:
  • polyA-binding protein II,
  • PABP2,
  • FBgn0005648,
  • PABPN1,
  • ROX2,
  • CG2163,
  • FBan0002163,
  • dpabII,
  • nuclear poly(A)-binding protein

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23 Alleles

DB identifier Symbol Allele Class Organism
FBal0286409 Pabp2[Scer\UAS.ORF]   Drosophila melanogaster
FBal0286410 Pabp2[Scer\UAS.ORF.T:Ivir\HA1]   Drosophila melanogaster
FBal0219382 Pabp2[55] loss of function allele Drosophila melanogaster
FBal0219383 Pabp2[6] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0219384 Pabp2[+t.g]   Drosophila melanogaster
FBal0219385 Pabp2[I61S.g]   Drosophila melanogaster
FBal0219386 Pabp2[ZCL3178]   Drosophila melanogaster
FBal0211716 Pabp2[CC00380]   Drosophila melanogaster
FBal0182358 Pabp2[d11110]   Drosophila melanogaster
FBal0257241 Pabp2[HMS00553]   Drosophila melanogaster
FBal0156111 Pabp2[Wee-P59]   Drosophila melanogaster
FBal0182359 Pabp2[d09497]   Drosophila melanogaster
FBal0182357 Pabp2[e02513]   Drosophila melanogaster
FBal0130834 Pabp2[EP2264] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0130833 Pabp2[KG02359]   Drosophila melanogaster
FBal0287786 Pabp2[EP-558]   Drosophila melanogaster
FBal0212871 Pabp2[3]   Drosophila melanogaster
FBal0208000 Pabp2[GD9743]   Drosophila melanogaster
FBal0215537 Pabp2[01]   Drosophila melanogaster
FBal0228334 Pabp2[NP5913]   Drosophila melanogaster
FBal0228335 Pabp2[SH0928]   Drosophila melanogaster
FBal0231957 Pabp2[KK102711]   Drosophila melanogaster
FBal0273066 Pabp2[NIG.2163R]   Drosophila melanogaster

99 Clones

Secondary Identifier DB identifier
bs19b10 FBcl0053793
EP02562 FBcl0084655
EP08827 FBcl0084701
EP11562 FBcl0084709
EN05137 FBcl0098163
EN05753 FBcl0098165
EN03044 FBcl0098171
EN15131 FBcl0098181
EK161752 FBcl0134720
EK156339 FBcl0134732
EK208750 FBcl0134882
EK073623 FBcl0134896
EK107150 FBcl0134904
EK226142 FBcl0134908
EK122956 FBcl0134912
EK215606 FBcl0134914
EK198851 FBcl0134920
EK221803 FBcl0134936
EK262031 FBcl0134952
EK185219 FBcl0134956
EK109052 FBcl0134958
EK108752 FBcl0134960
EK023758 FBcl0134964
EK303729 FBcl0134968
EK228440 FBcl0134994
EK095120 FBcl0135074
GM06716 FBcl0142350
GM18987 FBcl0147021
LD17671 FBcl0160539
LD17679 FBcl0160544

7 Exons

DB identifier Symbol
FBgn0005648:1 Pabp2:1
FBgn0005648:2 Pabp2:2
FBgn0005648:3 Pabp2:3
FBgn0005648:4 Pabp2:4
FBgn0005648:5 Pabp2:5
FBgn0005648:7 Pabp2:7
FBgn0005648:6 Pabp2:6

2 Transcripts

DB identifier Gene
FBtr0088785 Pabp2
FBtr0088786 Pabp2

4 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0088785-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0088786-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0088785-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0088786-3-prime-utr Drosophila melanogaster

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2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
35788 NCBI Entrez Gene identifiers FBgn0005648
61644 BioGRID FBgn0005648

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0005648 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 2530.0
FBgn0005648 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 2013.0
FBgn0005648 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 1045.0
FBgn0005648 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 1077.0
FBgn0005648 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 1832.0
FBgn0005648 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 2611.0
FBgn0005648 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 965.0
FBgn0005648 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 1157.0
FBgn0005648 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 1968.0
FBgn0005648 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 2187.0
FBgn0005648 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 2346.0
FBgn0005648 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 1358.0
FBgn0005648 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 2062.0
FBgn0005648 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 2188.0
FBgn0005648 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 2230.0
FBgn0005648 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 1867.0
FBgn0005648 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 2455.0
FBgn0005648 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 1986.0
FBgn0005648 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 2495.0
FBgn0005648 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 2201.0
FBgn0005648 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 2112.0
FBgn0005648 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 2510.0
FBgn0005648 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 1986.0
FBgn0005648 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 1430.0
FBgn0005648 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 2160.0
FBgn0005648 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 2261.0
FBgn0005648 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 1992.0
FBgn0005648 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 2853.0
FBgn0005648 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 2846.0
FBgn0005648 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 3225.0

6 Introns

DB identifier
Organism . Name
intron_FBgn0005648:1_FBgn0005648:2 Drosophila melanogaster
intron_FBgn0005648:2_FBgn0005648:3 Drosophila melanogaster
intron_FBgn0005648:3_FBgn0005648:4 Drosophila melanogaster
intron_FBgn0005648:4_FBgn0005648:5 Drosophila melanogaster
intron_FBgn0005648:5_FBgn0005648:7 Drosophila melanogaster
intron_FBgn0005648:4_FBgn0005648:6 Drosophila melanogaster

33 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage Pabp2 Increased lipid droplet area 7.994885844   19067489
Lipid storage Pabp2 Increased lipid droplet area 4.017752499   19067489
ERK signaling Pabp2 ERK activation reduced weak   17086199
Cytokinesis regulation Pabp2 Binucleate cells with decreased viability medium   15547975
Constitutive protein secretion and Golgi organization (1) Pabp2 Decreased horseradish peroxidase protein expression sp   16452979
Cell size and cell-cycle regulation (1) Pabp2 Decreased G1 DNA content, increased cytokinesis sp   16496002
Cell size and cell-cycle regulation (1) Pabp2 none sp   16496002
Cell size and cell-cycle regulation (2) Pabp2 none 1.2   16496002
Cell size and cell-cycle regulation (3) Pabp2 none 469   16496002
Candida albicans phagocytosis (1) Pabp2 none np   16336044
Combinatorial effect with methyl methanesulphonate (2) Pabp2 none sp   19543366
Mutant human huntingtin aggregation Pabp2 Decreased mutant human huntingtin aggregation <= -2   19789644
Muscle morphogenesis and function (1) Pabp2 Lethal np   20220848
Muscle morphogenesis and function (2) Pabp2 Wing posture / locomotion / ability to fly defect or lethal / semi-lethal np   20220848
Muscle morphogenesis and function (3) Pabp2 Fading Z-line np   20220848
Heat nociception (1) Pabp2 none -1.17   21074052
Heart development and function (1) Pabp2 none 1   20371351
Serratia marcescens infection (1) Pabp2 none 0.48076923076923   19520911
Notch pathway regulation (4) Pabp2 none 0   19363474
Self-renewal and differentiation in neural stem cells Pabp2 GFP aggregates number, GFP aggregates size, neuroblast cell shape, ganglion mother cell shorter lineages, ganglion mother cell shape, neuroblast underproliferation, lethal sp   21549331
Pol II elongation Pabp2 none 87 20 min heat shock 19279664
Notch pathway regulation (1) Pabp2 Downregulation of Notch pathway np   20493818
Notch pathway regulation (2) Pabp2 Downregulation of Notch pathway; adult wing margin: notches sp C96-GAL4 20493818
Notch pathway regulation (2) Pabp2 Lethal very strong en-GAL4 20493818
Adiposity regulation (1) Pabp2 none 0.254   20074523
RTK-Ras-ERK pathway regulation (1) Pabp2 none -0.1 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) Pabp2 Decreased ERK phosphorylation after EGF stimulation -1.74 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Pabp2 Increased ERK phosphorylation after sSpitz and EGF stimulation 1.68 10 minutes sSpitz stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Pabp2 Increased ERK phosphorylation after sSpitz and EGF stimulation 2.51 30 minutes sSpitz stimulation 22028469
Hippo pathway regulation Pabp2 none -2.57   23263283

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