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Gene : Rpn8 D. melanogaster

DB identifier  ? FBgn0002787 Secondary Identifier  ? CG3416
Name  ? Regulatory particle non-ATPase 8 Source  FlyBase
  • synonyms:
  • Mov34,
  • FBan0003416,
  • PRSC_DROME,
  • unnamed,
  • FBgn0002787,
  • p39B,
  • l(2)k08003,
  • RPN8,
  • S12,
  • FBgn0022065,
  • CG3416

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12 Alleles

DB identifier Symbol Allele Class Organism
FBal0283810 Rpn8[EP687]   Drosophila melanogaster
FBal0286522 Rpn8[Scer\UAS.ORF]   Drosophila melanogaster
FBal0286523 Rpn8[Scer\UAS.ORF.T:Ivir\HA1]   Drosophila melanogaster
FBal0245447 Rpn8[JF01140]   Drosophila melanogaster
FBal0064356 Rpn8[k16724]   Drosophila melanogaster
FBal0231195 Rpn8[KK101319]   Drosophila melanogaster
FBal0207640 Rpn8[GD10960]   Drosophila melanogaster
FBal0212438 Rpn8[MtnA.N.T:Avic\GFP]   Drosophila melanogaster
FBal0212439 Rpn8[MtnA.C.T:Avic\GFP]   Drosophila melanogaster
FBal0064357 Rpn8[k08003]   Drosophila melanogaster
FBal0262799 Rpn8[GL00333]   Drosophila melanogaster
FBal0288108 Rpn8[C125]   Drosophila melanogaster

203 Clones

Secondary Identifier DB identifier
AT18377 FBcl0008675
AT12201 FBcl0010967
AT13776 FBcl0011035
AT25105 FBcl0012487
AT07973 FBcl0012535
AT15740 FBcl0012555
bs80g08 FBcl0048599
EK254226 FBcl0098964
GM02223 FBcl0138829
GM03721 FBcl0138833
GM07730 FBcl0138849
GM10795 FBcl0138861
GM09629 FBcl0138871
HL02986 FBcl0150238
LD18147 FBcl0159997
LD08476 FBcl0160013
LD36460 FBcl0175204
LD45989 FBcl0175253
LD22193 FBcl0175506
LP14047 FBcl0188556
LP11805 FBcl0188571
LP20261 FBcl0188724
RE21904 FBcl0227355
RE15848 FBcl0227391
RE74124 FBcl0227404
AT21309 FBcl0348937
RP003139934 FBcl0618767
RP003196789 FBcl0618768
RP003574258 FBcl0653046
RP003354416 FBcl0653049

4 Exons

DB identifier Symbol
FBgn0002787:1 Mov34:1
FBgn0002787:3 Mov34:3
FBgn0002787:2 Mov34:2
FBgn0002787:4 Mov34:4

3 Transcripts

DB identifier Gene
FBtr0332921 Rpn8
FBtr0072290 Rpn8
FBtr0330237 Rpn8

6 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0072290-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0330237-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0332921-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0072290-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0330237-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0332921-3-prime-utr Drosophila melanogaster

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74 Pathways

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
37894 NCBI Entrez Gene identifiers FBgn0002787
63468 BioGRID FBgn0002787

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0002787 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 1861.0
FBgn0002787 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 1739.0
FBgn0002787 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 1143.0
FBgn0002787 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 2961.0
FBgn0002787 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 1967.0
FBgn0002787 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 1239.0
FBgn0002787 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 884.0
FBgn0002787 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 1563.0
FBgn0002787 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 884.0
FBgn0002787 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 919.0
FBgn0002787 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 1461.0
FBgn0002787 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 1731.0
FBgn0002787 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 1113.0
FBgn0002787 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 1657.0
FBgn0002787 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 1946.0
FBgn0002787 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 1761.0
FBgn0002787 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 1113.0
FBgn0002787 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 1532.0
FBgn0002787 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 2273.0
FBgn0002787 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 1336.0
FBgn0002787 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 1638.0
FBgn0002787 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 1612.0
FBgn0002787 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 1191.0
FBgn0002787 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 1618.0
FBgn0002787 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 1212.0
FBgn0002787 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 4220.0
FBgn0002787 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 684.0
FBgn0002787 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 1020.0
FBgn0002787 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 1092.0
FBgn0002787 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 1048.0

3 Introns

DB identifier
Organism . Name
intron_FBgn0002787:1_FBgn0002787:3 Drosophila melanogaster
intron_FBgn0002787:3_FBgn0002787:4 Drosophila melanogaster
intron_FBgn0002787:2_FBgn0002787:4 Drosophila melanogaster

29 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage Rpn8 none 0.905436716   19067489
Lipid storage Rpn8 none 1.744428138   19067489
ERK signaling Rpn8 ERK activation reduced weak   17086199
Cytokinesis regulation Rpn8 Binucleate cells with microtubule extensions weak   15547975
Intracellular Listeria monocytogenes infection Rpn8 Decreased GFP protein expression strong   16020693
L. monocytogenes infection Rpn8 Less infected cells or fewer bacteria per cell in LLO- strain ***   16157870
Hedgehog signaling Rpn8 Decreased Hedgehog reporter activity -2.59   16311596
Constitutive protein secretion and Golgi organization (1) Rpn8 Decreased horseradish peroxidase protein expression sp   16452979
Cell size and cell-cycle regulation (1) Rpn8 Decreased viability sp   16496002
Cell size and cell-cycle regulation (2) Rpn8 none 1.052   16496002
Cell size and cell-cycle regulation (3) Rpn8 Decreased cell number 378   16496002
Cell size and cell-cycle regulation (4) Rpn8 none below threshold   16496002
Candida albicans phagocytosis (1) Rpn8 none np   16336044
Combinatorial effect with methyl methanesulphonate (2) Rpn8 none sp   19543366
Mutant human huntingtin aggregation Rpn8 Decreased mutant human huntingtin aggregation <= -2   19789644
Heat nociception (1) Rpn8 none -1.17   21074052
Serratia marcescens infection (1) Rpn8 none -0.904109589041095   19520911
Serratia marcescens infection (1) Rpn8 none -0.642857142857142   19520911
Notch pathway regulation (4) Rpn8 Completely lethal (before pupal) sp   19363474
PGN-induced dJNK phosphorylation Rpn8 Increased P-JNK protein expression with PGN 2.71 15 min PGN induction 19893628
Hh pathway regulation Rpn8 none -0.225300586695009   17903264
Hh pathway regulation Rpn8 Downregulation of Hh pathway -0.487917745118115   17903264
Self-renewal and differentiation in neural stem cells Rpn8 GFP aggregates number, GFP aggregates size, neuroblast cell shape, ganglion mother cell larger cell size, ganglion mother cell shorter lineages, neuroblast underproliferation, lethal sp   21549331
Adiposity regulation (1) Rpn8 none -0.425   20074523
RTK-Ras-ERK pathway regulation (1) Rpn8 Decreased ERK phosphorylation after EGF stimulation -2.62 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) Rpn8 Decreased ERK phosphorylation after EGF stimulation -6.09 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Rpn8 Decreased ERK phosphorylation after sSpitz and EGF stimulation -1.77 30 minutes sSpitz stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Rpn8 none 1.43 10 minutes sSpitz stimulation 22028469
Hippo pathway regulation Rpn8 none -0.28   23263283

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