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Gene : Hsp83 D. melanogaster

DB identifier  ? FBgn0001233 Secondary Identifier  ? CG1242
Name  ? Heat shock protein 83 Source  FlyBase
  • synonyms:
  • l(3)j5C2,
  • anon-EST:Liang-2.53,
  • Enhancer of sevenless 3A,
  • en(lz)3C/4C,
  • 143198_at,
  • heat shock protein 83,
  • HSP83,
  • heat-shock protein 90 kDa,
  • FBgn0010233,
  • anon-WO0068693,
  • FBgn0004639,
  • anon-WO0140519.209,
  • FBan0001242,
  • FBgn0024852,
  • Su(Raf)3A,
  • CG1242,
  • FBgn0016742,
  • hsp84,
  • HSP82,
  • Enhancer of seven in absentia 2,
  • FBgn0011792,
  • DMHSP82,
  • HSP90,
  • E(sev)3A,
  • FBgn0044664,
  • 83,
  • stc,
  • scratch,
  • E(sina)2,
  • FBgn0001233,
  • clone 2.53,
  • ORF1,
  • 83K HSP,
  • ms(3)08445

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79 Alleles

DB identifier Symbol Allele Class Organism
FBal0282112 Hsp83[rev22]   Drosophila melanogaster
FBal0183161 Hsp83[d10181]   Drosophila melanogaster
FBal0257477 Hsp83[HMS00796]   Drosophila melanogaster
FBal0183160 Hsp83[f04920]   Drosophila melanogaster
FBal0257574 Hsp83[HMS00899]   Drosophila melanogaster
FBal0183162 Hsp83[c01018]   Drosophila melanogaster
FBal0160299 Hsp83[EY02456]   Drosophila melanogaster
FBal0028548 Hsp83[08445]   Drosophila melanogaster
FBal0028382 Hsp83[j5C2]   Drosophila melanogaster
FBal0060640 Hsp83[P582] antimorphic allele - genetic evidence, loss of function allele Drosophila melanogaster
FBal0042628 Hsp83[+t7.5]   Drosophila melanogaster
FBal0033759 Hsp83[+tpSPHW]   Drosophila melanogaster
FBal0126524 Hsp83[3C]   Drosophila melanogaster
FBal0060637 Hsp83[hs.2sev]   Drosophila melanogaster
FBal0123150 Hsp83[dsRNA.cMa]   Drosophila melanogaster
FBal0029643 Hsp83[e4A] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0086820 Hsp83[unspecified]   Drosophila melanogaster
FBal0126523 Hsp83[4C]   Drosophila melanogaster
FBal0176096 Hsp83[DeltaCd.MtnA]   Drosophila melanogaster
FBal0049165 Hsp83[9J1] antimorphic allele - genetic evidence Drosophila melanogaster
FBal0135974 Hsp83[dsRNA.cRa]   Drosophila melanogaster
FBal0049164 Hsp83[19F2] antimorphic allele - genetic evidence Drosophila melanogaster
FBal0029641 Hsp83[e1D] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0033762 Hsp83[H3]   Drosophila melanogaster
FBal0049163 Hsp83[13F3] antimorphic allele - genetic evidence Drosophila melanogaster
FBal0029644 Hsp83[e6A] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0029642 Hsp83[e3A] hypomorphic allele - genetic evidence Drosophila melanogaster
FBal0029645 Hsp83[e6D] antimorphic allele - genetic evidence Drosophila melanogaster
FBal0097248 Hsp83[DeltaHDE+TCE.T:Ecol\lacZ]   Drosophila melanogaster
FBal0097247 Hsp83[1.350hs.T:Ecol\lacZ]   Drosophila melanogaster

593 Clones

Secondary Identifier DB identifier
ESG0111d.B21_F06 FBcl0000224
AT16207 FBcl0003505
AT20544 FBcl0005425
AT14479 FBcl0005569
AT29911 FBcl0006121
AT12413 FBcl0006481
EC40892 FBcl0063813
EP02319 FBcl0075597
EK105939 FBcl0088844
EK165448 FBcl0088856
EK069451 FBcl0089224
EK258601 FBcl0089336
EK050429 FBcl0089366
EK242639 FBcl0089486
EN01737 FBcl0091899
EN03703 FBcl0092091
EN01927 FBcl0092111
EN15620 FBcl0092127
EN04056 FBcl0092845
GH01284 FBcl0105197
GH28786 FBcl0105311
GH08581 FBcl0105475
GH10546 FBcl0105735
GH22938 FBcl0105863
GH18787 FBcl0105967
GH10068 FBcl0106161
GH25713 FBcl0106473
GH15132 FBcl0106793
GH15219 FBcl0106875
GH12135 FBcl0107145

3 Exons

DB identifier Symbol
FBgn0001233:2 Hsp83:2
FBgn0001233:3 Hsp83:3
FBgn0001233:1 Hsp83:1

2 Transcripts

DB identifier Gene
FBtr0073040 Hsp83
FBtr0332873 Hsp83

4 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0073040-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0332873-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0073040-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0332873-3-prime-utr Drosophila melanogaster

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2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
38389 NCBI Entrez Gene identifiers FBgn0001233
63886 BioGRID FBgn0001233

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0001233 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 9802.0
FBgn0001233 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 8893.0
FBgn0001233 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 8997.0
FBgn0001233 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 15202.0
FBgn0001233 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 11192.0
FBgn0001233 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 14906.0
FBgn0001233 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 11100.0
FBgn0001233 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 15273.0
FBgn0001233 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 10530.0
FBgn0001233 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 11882.0
FBgn0001233 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 9062.0
FBgn0001233 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 11303.0
FBgn0001233 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 8416.0
FBgn0001233 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 18959.0
FBgn0001233 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 10103.0
FBgn0001233 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 12323.0
FBgn0001233 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 10029.0
FBgn0001233 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 11259.0
FBgn0001233 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 10994.0
FBgn0001233 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 8715.0
FBgn0001233 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 11809.0
FBgn0001233 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 9331.0
FBgn0001233 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 6608.0
FBgn0001233 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 7135.0
FBgn0001233 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 6728.0
FBgn0001233 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 13745.0
FBgn0001233 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 4906.0
FBgn0001233 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 2762.0
FBgn0001233 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 2054.0
FBgn0001233 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 2513.0

2 Introns

DB identifier
Organism . Name
intron_FBgn0001233:2_FBgn0001233:3 Drosophila melanogaster
intron_FBgn0001233:1_FBgn0001233:3 Drosophila melanogaster

36 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage Hsp83 none 0.096240756   19067489
Lipid storage Hsp83 none 1.542844171   19067489
ERK signaling Hsp83 ERK activation increased weak   17086199
E. coli / S. aureus infection Hsp83 Decreased phagocytosis np   11912489
Cell morphology Hsp83 Morphology np   14527345
Cell size and cell-cycle regulation (1) Hsp83 none sp   16496002
Mitosis Hsp83 Chromosome misalignment np   17412918
Combinatorial effect with methyl methanesulphonate (1) Hsp83 none sp   19543366
Combinatorial effect with methyl methanesulphonate (2) Hsp83 none sp   19543366
Muscle morphogenesis and function (1) Hsp83 Lethal np   20220848
Muscle morphogenesis and function (3) Hsp83 Split myofibril, fading Z-line np   20220848
Heat nociception (1) Hsp83 Developmentally lethal -1.17   21074052
Heart development and function (1) Hsp83 Pupal lethal 0.14   20371351
Heart development and function (2) Hsp83 Decreased viability 3.99   20371351
Serratia marcescens infection (1) Hsp83 none -0.189189189189189   19520911
Notch pathway regulation (4) Hsp83 Completely lethal (before pupal) sp   19363474
Notch pathway regulation (1) Hsp83 Upregulation of Notch pathway np   20493818
Notch pathway regulation (2) Hsp83 Lethal strong en-GAL4 20493818
Notch pathway regulation (2) Hsp83 none np C96-GAL4 20493818
Notch pathway regulation (2) Hsp83 Up- and downregulation of Notch pathway; wing disc NRE:EGFP: up, down, broader; wing disc myrRFP: accumulation; lethal sp en-GAL4 20493818
Notch pathway regulation (2) Hsp83 Upregulation of Notch pathway; wing disc NRE:EGFP: up; lethal sp en-GAL4 20493818
Notch pathway regulation (2) Hsp83 Upregulation of Notch pathway; wing disc size: overgrown; wing disc NRE:EGFP: up, gap; wing disc myrRFP: reduced; lethal sp en-GAL4 20493818
Notch pathway regulation (3) Hsp83 Upregulation of Notch pathway np   20493818
Adiposity regulation (1) Hsp83 Decreased triglyceride expression -1   20074523
Adiposity regulation (2) Hsp83 Lethal or developmental delay d/l   20074523
Adiposity regulation (3) Hsp83 Lethal or developmental delay d/l   20074523
Adiposity regulation (4) Hsp83 Lethal or developmental delay d/l   20074523
Adiposity regulation (5) Hsp83 Lethal or developmental delay d/l   20074523
Secretory pathway regulation Hsp83 Decreased BiP signal peptide and firefly luciferase fusion protein expression < -2   19942856
RTK-Ras-ERK pathway regulation (1) Hsp83 none 0.74 0 minutes EGF stimulation 22028469

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