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Gene : CycA D. melanogaster

DB identifier  ? FBgn0000404 Secondary Identifier  ? CG5940
Name  ? Cyclin A Source  FlyBase
  • synonyms:
  • DmcycA,
  • dCycA,
  • 0545/13,
  • 0521/06,
  • FBgn0000404,
  • FBgn0010826,
  • l(3)03946,
  • l(3)j3C8,
  • hari,
  • l(3)68Ea,
  • FBgn0011353,
  • rsg11,
  • 0040/24,
  • CyclinA,
  • CLD3,
  • CYCA,
  • FBan0005940,
  • cyclin A,
  • anon-WO0140519.128,
  • 0104/07,
  • 0046/23,
  • Cyc A,
  • 1449/05,
  • 0033/02,
  • rose-gespleten region interval 11,
  • CG5940,
  • 1329/16,
  • l(3)183,
  • 0245/34,
  • l(3)neo114,
  • l(3)rsg11,
  • FBgn0044754,
  • Suppressor of rux 3B,
  • S(rux)3B

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104 Alleles

DB identifier Symbol Allele Class Organism
FBal0245370 CycA[HM04073]   Drosophila melanogaster
FBal0184265 CycA[c06664]   Drosophila melanogaster
FBal0184266 CycA[c06568]   Drosophila melanogaster
FBal0160677 CycA[EY11746]   Drosophila melanogaster
FBal0002203 CycA[5]   Drosophila melanogaster
FBal0160674 CycA[c05304]   Drosophila melanogaster
FBal0083562 CycA[S144914]   Drosophila melanogaster
FBal0083563 CycA[S144911]   Drosophila melanogaster
FBal0083564 CycA[S144905]   Drosophila melanogaster
FBal0029122 CycA[ry40]   Drosophila melanogaster
FBal0083565 CycA[S132916]   Drosophila melanogaster
FBal0083566 CycA[S054513]   Drosophila melanogaster
FBal0083567 CycA[S052119]   Drosophila melanogaster
FBal0083568 CycA[S052118]   Drosophila melanogaster
FBal0083569 CycA[S052106]   Drosophila melanogaster
FBal0083570 CycA[S024534]   Drosophila melanogaster
FBal0083571 CycA[S010407]   Drosophila melanogaster
FBal0083572 CycA[S004623]   Drosophila melanogaster
FBal0083573 CycA[S004024]   Drosophila melanogaster
FBal0083574 CycA[S003302a]   Drosophila melanogaster
FBal0010941 CycA[j3C8]   Drosophila melanogaster
FBal0009496 CycA[03946]   Drosophila melanogaster
FBal0124345 CycA[delta1-53.Scer\UAS]   Drosophila melanogaster
FBal0124351 CycA[delta1-109.Scer\UAS]   Drosophila melanogaster
FBal0124350 CycA[delta1-131.Scer\UAS]   Drosophila melanogaster
FBal0124344 CycA[delta1-83.Scer\UAS]   Drosophila melanogaster
FBal0124346 CycA[delta1-38.Scer\UAS]   Drosophila melanogaster
FBal0124342 CycA[delta32-53.Scer\UAS]   Drosophila melanogaster
FBal0124343 CycA[delta17-53.Scer\UAS]   Drosophila melanogaster
FBal0124349 CycA[delta1-13,32-53.Scer\UAS]   Drosophila melanogaster

368 Clones

Secondary Identifier DB identifier
LD13696 FBcl0349829
DPiM_LD44443 FBcl0741257
AT16456 FBcl0037307
UUGC1034 FBcl0005531
AT31333 FBcl0037281
AT18381 FBcl0037289
AT29724 FBcl0037291
EK249863 FBcl0075450
EK120021 FBcl0075478
EK044349 FBcl0075504
EK096107 FBcl0076168
EK268849 FBcl0076206
EK250540 FBcl0076218
EK253512 FBcl0076228
EK206828 FBcl0076240
EK295914 FBcl0076250
EK125917 FBcl0076378
EK123051 FBcl0076418
EK247050 FBcl0076432
EK073354 FBcl0076446
EK207614 FBcl0076458
EK303419 FBcl0076580
EK266510 FBcl0076604
EK301938 FBcl0076614
EK234114 FBcl0081056
EK243931 FBcl0081650
EK188833 FBcl0081730
EK224531 FBcl0082964
EK262347 FBcl0083352
EP11259 FBcl0086969

10 Exons

DB identifier Symbol
FBgn0000404:7 CycA:7
FBgn0000404:1 CycA:1
FBgn0000404:10 CycA:10
FBgn0000404:8 CycA:8
FBgn0000404:6 CycA:6
FBgn0000404:5 CycA:5
FBgn0000404:4 CycA:4
FBgn0000404:3 CycA:3
FBgn0000404:2 CycA:2
FBgn0000404:9 CycA:9

3 Transcripts

DB identifier Gene
FBtr0304650 CycA
FBtr0076075 CycA
FBtr0076076 CycA

4 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0076075-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0304650-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0076075-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0304650-3-prime-utr Drosophila melanogaster

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62 Pathways

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
39340 NCBI Entrez Gene identifiers FBgn0000404
64701 BioGRID FBgn0000404

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from UniProt  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0000404 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 1637.0
FBgn0000404 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 1761.0
FBgn0000404 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 831.0
FBgn0000404 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 1378.0
FBgn0000404 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 1136.0
FBgn0000404 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 2297.0
FBgn0000404 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 859.0
FBgn0000404 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 2013.0
FBgn0000404 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 1126.0
FBgn0000404 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 1783.0
FBgn0000404 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 2003.0
FBgn0000404 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 911.0
FBgn0000404 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 1106.0
FBgn0000404 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 2339.0
FBgn0000404 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 1773.0
FBgn0000404 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 1465.0
FBgn0000404 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 1186.0
FBgn0000404 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 1561.0
FBgn0000404 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 1286.0
FBgn0000404 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 1257.0
FBgn0000404 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 1333.0
FBgn0000404 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 2726.0
FBgn0000404 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 1341.0
FBgn0000404 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 1161.0
FBgn0000404 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 1623.0
FBgn0000404 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 12835.0
FBgn0000404 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 9861.0
FBgn0000404 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 7310.0
FBgn0000404 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 5733.0
FBgn0000404 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 5328.0

10 Introns

DB identifier
Organism . Name
intron_FBgn0000404:9_FBgn0000404:8 Drosophila melanogaster
intron_FBgn0000404:8_FBgn0000404:6 Drosophila melanogaster
intron_FBgn0000404:6_FBgn0000404:5 Drosophila melanogaster
intron_FBgn0000404:5_FBgn0000404:4 Drosophila melanogaster
intron_FBgn0000404:4_FBgn0000404:3 Drosophila melanogaster
intron_FBgn0000404:3_FBgn0000404:2 Drosophila melanogaster
intron_FBgn0000404:10_FBgn0000404:7 Drosophila melanogaster
intron_FBgn0000404:7_FBgn0000404:6 Drosophila melanogaster
intron_FBgn0000404:3_FBgn0000404:1 Drosophila melanogaster
intron_FBgn0000404:10_FBgn0000404:8 Drosophila melanogaster

35 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage CycA none 0.276003954   19067489
Lipid storage CycA none 0.793025832   19067489
Lipid storage CycA none 5.733871899   19067489
Lipid storage CycA none -2.696809393   19067489
ERK signaling CycA ERK activation reduced strong   17086199
Cytokinesis regulation CycA Binucleate cells with large, diffuse DNA and decreased viability weak   15547975
Intracellular Listeria monocytogenes infection CycA Increased GFP protein expression moderate   16020693
Constitutive protein secretion and Golgi organization (1) CycA Decreased horseradish peroxidase protein expression sp   16452979
Constitutive protein secretion and Golgi organization (1) CycA Decreased horseradish peroxidase protein expression sp   16452979
Cell size and cell-cycle regulation (1) CycA Decreased G1 DNA content, increased G1 cell size, increased cytokinesis sp   16496002
Cell size and cell-cycle regulation (2) CycA none 1.448   16496002
Cell size and cell-cycle regulation (3) CycA none 475   16496002
Cell size and cell-cycle regulation (4) CycA none below threshold   16496002
Embryonic nervous system development CycA Defects in nervous system development np   15534205
Lipid storage CycA Fewer lipid droplets strong   18408709
Combinatorial effect with methyl methanesulphonate (2) CycA none sp   19543366
Muscle morphogenesis and function (1) CycA Lethal np   20220848
Muscle morphogenesis and function (2) CycA Wing posture / locomotion / ability to fly defect or lethal / semi-lethal np   20220848
Heat nociception (1) CycA Increased noxious heat avoidance, lethal 6.53   21074052
Heat nociception (2) CycA none 32.33333333   21074052
Heart development and function (1) CycA none 1   20371351
Serratia marcescens infection (1) CycA none -0.472222222222222   19520911
Notch pathway regulation (4) CycA Loss of bristles, notum malformation migration, overproliferation, lateral inhibition sp   19363474
Notch pathway regulation (5) CycA Wrinkled, small wings, tufts of trichomes np   19363474
Notch pathway regulation (6) CycA none np   19363474
Notch pathway regulation (7) CycA Few sensory organ precursor cells, big sensory organ precursor cells np   19363474
Self-renewal and differentiation in neural stem cells CycA GFP aggregates number, GFP aggregates size, neuroblast abnormally large cell size, neuroblast larger cell size, neuroblast cell shape, ganglion mother cell shorter lineages, neuroblast underproliferation, lethal sp   21549331
Adiposity regulation (1) CycA none -0.053   20074523
Vaccinia virus infection CycA none sp   20585561
RTK-Ras-ERK pathway regulation (1) CycA none -0.29 0 minutes EGF stimulation 22028469

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