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Gene : Chc D. melanogaster

DB identifier  ? FBgn0000319 Secondary Identifier  ? CG9012
Name  ? Clathrin heavy chain Source  FlyBase
  • synonyms:
  • l(1)VI,
  • Cla,
  • Clathrin hc,
  • l(1)G0438,
  • D-Chc,
  • clathrin heavy chain,
  • CG9012,
  • FBgn0014972,
  • FBgn0028268,
  • l(1)13Fb,
  • chc1,
  • CHC,
  • FBgn0000319,
  • Clathrin,
  • CLH,
  • FBan0009012,
  • dCHC

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33 Alleles

DB identifier Symbol Allele Class Organism
FBal0283108 Chc[N.4C.T:Zzzz\FLAG,T:Zzzz\TC]   Drosophila melanogaster
FBal0283631 Chc[C.4C.T:Zzzz\FLAG,T:Zzzz\TC]   Drosophila melanogaster
FBal0263452 Chc[VDRC.cUa]   Drosophila melanogaster
FBal0243263 Chc[tCH322-123J21]   Drosophila melanogaster
FBal0277299 Chc[Scer\UAS.T:Avic\GFP-EGFP]   Drosophila melanogaster
FBal0264906 Chc[Scer\UAS.T:Disc\RFP-mRFP]   Drosophila melanogaster
FBal0240370 Chc[GF23]   Drosophila melanogaster
FBal0257878 Chc[HMS01222]   Drosophila melanogaster
FBal0100260 Chc[G0438]   Drosophila melanogaster
FBal0124371 Chc[BG02593a]   Drosophila melanogaster
FBal0131298 Chc[PG59]   Drosophila melanogaster
FBal0246725 Chc[wt.Scer\UAS]   Drosophila melanogaster
FBal0246726 Chc[A1082T.Scer\UAS]   Drosophila melanogaster
FBal0063566 Chc[CHC9]   Drosophila melanogaster
FBal0063567 Chc[CHC2]   Drosophila melanogaster
FBal0063568 Chc[+t13]   Drosophila melanogaster
FBal0033513 Chc[3] loss of function allele Drosophila melanogaster
FBal0033512 Chc[2]   Drosophila melanogaster
FBal0033511 Chc[1] loss of function allele Drosophila melanogaster
FBal0020040 Chc[4]   Drosophila melanogaster
FBal0136102 Chc[dsRNA.cRa]   Drosophila melanogaster
FBal0197294 Chc[BB2]   Drosophila melanogaster
FBal0197293 Chc[AA1]   Drosophila melanogaster
FBal0242269 Chc[JF02681]   Drosophila melanogaster
FBal0206558 Chc[GD14095]   Drosophila melanogaster
FBal0219619 Chc[+t14.3]   Drosophila melanogaster
FBal0220358 Chc[DN.Scer\UAS]   Drosophila melanogaster
FBal0264837 Chc[alphaTub..T:Ivir\HA1]   Drosophila melanogaster
FBal0264838 Chc[Scer\UAS.P\T.T:Disc\RFP-mCherry]   Drosophila melanogaster
FBal0264839 Chc[Scer\UAS.P\T.T:Avic\GFP-EGFP]   Drosophila melanogaster

274 Clones

Secondary Identifier DB identifier
DPiM_LD43101 FBcl0741837
AT09160 FBcl0007449
AT14780 FBcl0008759
ESG011a.E7.4_H02 FBcl0012441
ESG011a.E21_H02 FBcl0013273
bs28b01 FBcl0048281
bs34c09 FBcl0048377
EC38272 FBcl0062701
EP03952 FBcl0076061
EP05946 FBcl0076999
EP09261 FBcl0077001
EN10962 FBcl0092223
EN17212 FBcl0092309
EN01357 FBcl0092317
GH27939 FBcl0108649
GH10554 FBcl0116865
GH21014 FBcl0117191
GH10957 FBcl0118061
GH28707 FBcl0119991
GH25815 FBcl0120051
EK149343 FBcl0124600
EK200928 FBcl0124604
EK178056 FBcl0124646
EK307724 FBcl0124670
EK265035 FBcl0124728
EK162932 FBcl0124744
EK185833 FBcl0124776
EK090816 FBcl0124870
EK148353 FBcl0124874
EK165029 FBcl0124912

13 Exons

DB identifier Symbol
FBgn0000319:11 Chc:11
FBgn0000319:8 Chc:8
FBgn0000319:6 Chc:6
FBgn0000319:5 Chc:5
FBgn0000319:4 Chc:4
FBgn0000319:3 Chc:3
FBgn0000319:2 Chc:2
FBgn0000319:1 Chc:1
FBgn0000319:7 Chc:7
FBgn0000319:10 Chc:10
FBgn0000319:9 Chc:9
FBgn0000319:12 Chc:12
FBgn0000319:13 Chc:13

7 Transcripts

DB identifier Gene
FBtr0339445 Chc
FBtr0074179 Chc
FBtr0074182 Chc
FBtr0112797 Chc
FBtr0112798 Chc
FBtr0074180 Chc
FBtr0074181 Chc

14 UTRs

Class DB identifier
Organism . Name
FivePrimeUTR FBtr0074179-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0074180-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0074181-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0074182-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0112797-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0112798-5-prime-utr Drosophila melanogaster
FivePrimeUTR FBtr0339445-5-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0074179-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0074180-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0074181-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0074182-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0112797-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0112798-3-prime-utr Drosophila melanogaster
ThreePrimeUTR FBtr0339445-3-prime-utr Drosophila melanogaster

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2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
32537 NCBI Entrez Gene identifiers FBgn0000319
58885 BioGRID FBgn0000319

11 Data Sets

Name URL
FlyBase data set for Drosophila melanogaster  
Swiss-Prot data set http://ca.expasy.org/sprot
Drosophila 12 Genomes Consortium homology  
GenomeRNAi data set  
TreeFam data set  
Panther data set  
IntAct interactions data set  
BioGRID interaction data set http://www.thebiogrid.org/downloads.php
GO Annotation from FlyBase  
FlyBase fasta data set for Drosophila melanogaster  
Drosophila Cell Line and Developmental Stage Gene and Exon Scores  

55 Expression Scores


Gene . Primary Identifier

Submission . Title

Cell Line . Name

Developmental Stage . Name
Score
FBgn0000319 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME L1 3295.0
FBgn0000319 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Sg4 3465.0
FBgn0000319 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD11 1985.0
FBgn0000319 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c2 5022.0
FBgn0000319 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD20-c5 3287.0
FBgn0000319 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Kc167 3173.0
FBgn0000319 Drosophila Cell Line and Developmental Stage Gene and Exon Scores GM2 3333.0
FBgn0000319 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2-DRSC 2943.0
FBgn0000319 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S2R+ 2726.0
FBgn0000319 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S1 5286.0
FBgn0000319 Drosophila Cell Line and Developmental Stage Gene and Exon Scores 1182-4H 3713.0
FBgn0000319 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD16-c3 3894.0
FBgn0000319 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD32 3324.0
FBgn0000319 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD17-c3 2796.0
FBgn0000319 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD8 4677.0
FBgn0000319 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W1 Cl.8+ 2813.0
FBgn0000319 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD9 4083.0
FBgn0000319 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG1-c1 2740.0
FBgn0000319 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD21 3804.0
FBgn0000319 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmD4-c1 4136.0
FBgn0000319 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG3-c2 3113.0
FBgn0000319 Drosophila Cell Line and Developmental Stage Gene and Exon Scores S3 3069.0
FBgn0000319 Drosophila Cell Line and Developmental Stage Gene and Exon Scores CME W2 2861.0
FBgn0000319 Drosophila Cell Line and Developmental Stage Gene and Exon Scores mbn2 2589.0
FBgn0000319 Drosophila Cell Line and Developmental Stage Gene and Exon Scores ML-DmBG2-c2 3433.0
FBgn0000319 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 0-2 h 2793.0
FBgn0000319 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 2-4 h 2338.0
FBgn0000319 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 4-6 h 2559.0
FBgn0000319 Drosophila Cell Line and Developmental Stage Gene and Exon Scores Embryo 6-8 h 2035.0
FBgn0000319 Drosophila Cell Line and Developmental Stage Gene and Exon Scores emb 8-10h 1887.0

13 Introns

DB identifier
Organism . Name
intron_FBgn0000319:11_FBgn0000319:6 Drosophila melanogaster
intron_FBgn0000319:6_FBgn0000319:5 Drosophila melanogaster
intron_FBgn0000319:5_FBgn0000319:4 Drosophila melanogaster
intron_FBgn0000319:4_FBgn0000319:3 Drosophila melanogaster
intron_FBgn0000319:3_FBgn0000319:2 Drosophila melanogaster
intron_FBgn0000319:2_FBgn0000319:1 Drosophila melanogaster
intron_FBgn0000319:7_FBgn0000319:6 Drosophila melanogaster
intron_FBgn0000319:10_FBgn0000319:6 Drosophila melanogaster
intron_FBgn0000319:9_FBgn0000319:6 Drosophila melanogaster
intron_FBgn0000319:12_FBgn0000319:6 Drosophila melanogaster
intron_FBgn0000319:13_FBgn0000319:6 Drosophila melanogaster
intron_FBgn0000319:11_FBgn0000319:8 Drosophila melanogaster
intron_FBgn0000319:8_FBgn0000319:6 Drosophila melanogaster

33 RNAi Results

Screen Gene Phenotype Score Conditions PubMed ID
Lipid storage Chc none 0.414165944   19067489
Lipid storage Chc none 0.428851924   19067489
Lipid storage Chc none 0.073981187   19067489
Lipid storage Chc none 1.841637819   19067489
E. coli / S. aureus infection Chc Decreased phagocytosis np   11912489
Cytokinesis regulation Chc Binucleate cells weak   15547975
L. monocytogenes infection Chc Escape pff LLO- strain *   16157870
L. monocytogenes infection Chc Fewer infected cells, fewer bacteria per cell **   16157870
Cell size and cell-cycle regulation (1) Chc none sp   16496002
RNAi pathway Chc Decreased RNAi silencing np   16862146
RNAi pathway Chc Decreased dsRNA uptake np   16531407
CD4 regulation by human immunodeficiency virus Type 1 Nef (HIV-1 Nef) Chc Decreased human CD4 surface protein expression CD4 after human immunodeficiency virus Type 1 Nef (HIV-1 Nef) stimulation 1.01   17267500
Muscle morphogenesis and function (1) Chc Lethal np   20220848
Muscle morphogenesis and function (1) Chc Lethal np   20220848
Muscle morphogenesis and function (2) Chc Wing posture / locomotion / ability to fly defect or lethal / semi-lethal np   20220848
Heat nociception (1) Chc none -1.17   21074052
Heat nociception (1) Chc none -1.17   21074052
Heart development and function (1) Chc Adult lethal 0.63   20371351
Heart development and function (2) Chc Decreased viability 3.63   20371351
Serratia marcescens infection (1) Chc Decreased viability after Serratia marcescens infection -2.20253164556962   19520911
Serratia marcescens infection (2) Chc Decreased viability after Serratia marcescens infection sp   19520911
Serratia marcescens infection (6) Chc Larval lethality or failure to eclose np   19520911
Notch pathway regulation (4) Chc Completely lethal (before pupal) sp   19363474
Notch pathway regulation (4) Chc Completely lethal (before pupal) sp   19363474
Notch pathway regulation (1) Chc Downregulation of Notch pathway np   20493818
RTK-Ras-ERK pathway regulation (1) Chc Increased ERK phosphorylation after EGF stimulation 6.13 0 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (1) Chc Increased ERK phosphorylation after EGF stimulation 1.71 10 minutes EGF stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Chc none -0.05 30 minutes sSpitz stimulation 22028469
RTK-Ras-ERK pathway regulation (2) Chc none 0.44 10 minutes sSpitz stimulation 22028469
Wnt proteins secretion Chc none -1.9   22094269

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