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Changes in expression of small RNAs during aging in C. elegans

experiment: Changes in expression of small RNAs during aging in C. elegans project: The C. elegans Transcriptome PI: Robert Waterston Labs: Frank Slack
We report a significant number of miRNAs and other non-coding small RNAs show dramatic changes in expression during aging in C. elegans. RNAs were prepared from four diffrent timepoints during adulthood of C. elegans hermaphrodites, Day 0, 5, 8 and 12 post-L4 molt, and used for making cDNA libraries for small RNAs. Each library was sequenced using recent advances in high-throughput sequencing technology, Solexa. This study should lead to a better understanding of the aging process and age-related diseases.